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The literature suggests that HCV-infected patients may frequently have Sj\u00f6gren-like sialadenitis with mild clinical symptoms, whereas oral LP may be significantly associated with HCV infections in Southern Europe and Japan but not in Northern Europe. These geographical differences could be related to immunogenetic factors such as the HLA-DR6 allele, significantly expressed in Italian patients with OLP and HCV. Analysis of experimental data suggests that HCV could be involved in the pathogenesis of both these diseases. Moreover, parotid lymphoma may arise in patients with sialadenitis, mainly with type II cryoglobulinemia. Little attention has been paid to oral health needs in HCV-infected patients and the variable effect of interferon-alpha therapy on oral tissues. Further research is needed, because of the potentially great influence of oral diseases possibly linked to HCV on the quality of life of millions of patients. <\/jats:p>","DOI":"10.1177\/154411130301400205","type":"journal-article","created":{"date-parts":[[2009,1,9]],"date-time":"2009-01-09T00:40:32Z","timestamp":1231461632000},"page":"115-127","source":"Crossref","is-referenced-by-count":61,"title":["O<scp>ral<\/scp> D<scp>iseases<\/scp> P<scp>ossibly<\/scp> A<scp>ssociated with<\/scp> H<scp>epatitis<\/scp> C V<scp>irus<\/scp>"],"prefix":"10.1177","volume":"14","author":[{"given":"M.","family":"Carrozzo","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Oral Medicine Section, C. so Dogliotti 14, University of Turin, I-10126 Torino, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gandolfo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Human Oncology, Oral Medicine Section, C. so Dogliotti 14, University of Turin, I-10126 Torino, Italy;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,3,1]]},"reference":[{"key":"ACETI-ETAL-1992","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91252-4"},{"key":"AGNER-ETAL-1992","doi-asserted-by":"publisher","DOI":"10.2340\/0001555572380"},{"key":"ALMASIO-ETAL-1992","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91562-M"},{"key":"AMICHAI-ETAL-1994","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1994.tb03289.x"},{"key":"AREIAS-ETAL-1996","unstructured":"Areias J, Velho GC, Cerqueira R, Barbedo C, Amaral B, Sanches M, et al. 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