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Genetic factors account for at least 50% of the variation in EARR. Variation in the Interleukin 1 beta gene in orthodontically treated individuals accounts for 15% of the variation in EARR. Historical and contemporary evidence implicates injury to the periodontal ligament and supporting structures at the site of root compression following the application of orthodontic force as the earliest event leading to EARR. Decreased IL-1\u03b2 production in the case of IL-1B (+3953) allele 1 may result in relatively less catabolic bone modeling (resorption) at the cortical bone interface with the PDL, which may result in prolonged stress concentrated in the root of the tooth, triggering a cascade of fatigue-related events leading to root resorption. One mechanism of action for EARR may be mediated through impairment of alveolar resorption, resulting in prolonged stress and strain of the adjacent tooth root due to dynamic functional loads. Future estimation of susceptibility to EARR will likely require the analysis of a suite of genes, root morphology, skeleto-dental values, and the treatment method to be used\u2014or essentially the amount of tooth movement planned for treatment. <\/jats:p>","DOI":"10.1177\/154411130401500205","type":"journal-article","created":{"date-parts":[[2009,1,9]],"date-time":"2009-01-09T00:40:32Z","timestamp":1231461632000},"page":"115-122","source":"Crossref","is-referenced-by-count":138,"title":["G<scp>enetic<\/scp> F<scp>actors in<\/scp> E<scp>xternal<\/scp> A<scp>pical<\/scp> R<scp>oot<\/scp> R<scp>esorption and<\/scp> O<scp>rthodontic<\/scp> T<scp>reatment<\/scp>"],"prefix":"10.1177","volume":"15","author":[{"suffix":"Jr.","given":"J.K.","family":"Hartsfield","sequence":"first","affiliation":[{"name":"Department of Oral Facial Development, Indiana University School of Dentistry, 1121 West Michigan Street, Indianapolis, IN 46202-5186, USA; and"},{"name":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.T.","family":"Everett","sequence":"additional","affiliation":[{"name":"Department of Oral Facial Development, Indiana University School of Dentistry, 1121 West Michigan Street, Indianapolis, IN 46202-5186, USA; and"},{"name":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.A.","family":"Al-Qawasmi","sequence":"additional","affiliation":[{"name":"Department of Oral Facial Development, Indiana University School of Dentistry, 1121 West Michigan Street, Indianapolis, IN 46202-5186, USA; and"},{"name":"Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2004,3,1]]},"reference":[{"key":"ABECASIS-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1086\/302698"},{"key":"AL-QAWASMI-ETAL-2003A","doi-asserted-by":"publisher","DOI":"10.1067\/mod.2003.42"},{"key":"AL-QAWASMI-ETAL-2003B","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200506"},{"key":"ALHASHIMI-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1067\/mod.2001.110809"},{"key":"ALLISON-1997","unstructured":"Allison DB (1997). 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