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In so doing, TGF-\u03b2 plays a key role in the control of cell behavior in both health and disease. In this report, we review what is known about the mechanisms of activation of the peptide, together with details of TGF-\u03b2 signal transduction pathways. This review summarizes the evidence implicating TGF-\u03b2 in normal physiological processes of the craniofacial complex\u2014such as palatogenesis, tooth formation, wound healing, and scarring\u2014and then evaluates its role in non-malignant disease processes such as scleroderma, submucous fibrosis, periodontal disease, and lichen planus. <\/jats:p>","DOI":"10.1177\/154411130401500602","type":"journal-article","created":{"date-parts":[[2009,1,9]],"date-time":"2009-01-09T00:40:32Z","timestamp":1231461632000},"page":"324-336","source":"Crossref","is-referenced-by-count":50,"title":["TGF-\u03b2 S<scp>ignal<\/scp> T<scp>ransduction in<\/scp> O<scp>ro<\/scp>-<scp>facial<\/scp> H<scp>ealth and<\/scp> N<scp>on<\/scp>-<scp>malignant<\/scp> D<scp>isease <\/scp>(P<scp>art<\/scp> I)"],"prefix":"10.1177","volume":"15","author":[{"given":"S.S.","family":"Prime","sequence":"first","affiliation":[{"name":"Department of Oral and Dental Science, Division of Oral Medicine, Pathology and Microbiology, Bristol Dental Hospital and School, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Pring","sequence":"additional","affiliation":[{"name":"Department of Oral and Dental Science, Division of Oral Medicine, Pathology and Microbiology, Bristol Dental Hospital and School, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Oral and Dental Science, Division of Oral Medicine, Pathology and Microbiology, Bristol Dental Hospital and School, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.C.","family":"Paterson","sequence":"additional","affiliation":[{"name":"Department of Oral and Dental Science, Division of Oral Medicine, Pathology and Microbiology, Bristol Dental Hospital and School, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2004,11,1]]},"reference":[{"key":"bibr-AGHDASI-ETAL-2001","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.041614198"},{"key":"bibr-ANNES-ETAL-2003","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00229"},{"key":"bibr-ASHCROFT-ETAL-1999","doi-asserted-by":"publisher","DOI":"10.1038\/12944"},{"key":"bibr-ATFI-ETAL-1997","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.3.1429"},{"key":"bibr-ATTISANO-AND-WRANA-2000","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(99)00081-2"},{"key":"bibr-BAKIN-ETAL-2000","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M005912200"},{"key":"bibr-BANDYOPADHYAY-ETAL-2002","unstructured":"Bandyopadhyay A, Lopez-Casillas F, Malik SN, Montiel JL, Mendoza V, Yang J, et al. 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