{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:55:58Z","timestamp":1777942558038,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31 HL 141008"],"award-info":[{"award-number":["F31 HL 141008"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL147866"],"award-info":[{"award-number":["R01 HL147866"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS064034"],"award-info":[{"award-number":["R01 NS064034"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal for Vascular Ultrasound"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Transcranial Doppler (TCD) has been used to identify microembolic signals (MES) in individuals with carotid atherosclerosis (CAS). The MES are hypothesized to originate from unstable carotid plaque and have been identified in symptomatic and asymptomatic individuals with CAS. The purpose of this study is to examine the relationship of clinical risk factors for stroke (CRFs) and the presence of MES in patients with advanced CAS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Participants scheduled for carotid endarterectomy (CEA) (&gt;60% stenosis NASCET and ACAS Criteria) were preoperatively evaluated for CRFs and the presence of MES with TCD. Kendall tau correlation coefficients, Pearson \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      , and logistic regression analysis were used to examine the relationship between MES and CRFs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Participants (n = 89) had a median (interquartile range) age of 71 (13) years, 30 (33.7%) were female, and 53 (59.6%) were symptomatic. Microembolic signals were detected in 32 (36%) participants. There was significant evidence of association between MES with older age (\n                      <jats:italic>P<\/jats:italic>\n                      = .026) and male sex (\n                      <jats:italic>P<\/jats:italic>\n                      = .007). No other clinical variables showed significant association with MES (all\n                      <jats:italic>P<\/jats:italic>\n                      -values &gt; .05). Logistic regression demonstrated that a model including age (\n                      <jats:italic>P<\/jats:italic>\n                      = .018), sex (\n                      <jats:italic>P<\/jats:italic>\n                      = .013) and hyperlipidemia (\n                      <jats:italic>P<\/jats:italic>\n                      = .083) was significantly associated with the presence of MES (\n                      <jats:italic>P<\/jats:italic>\n                      = .001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Microembolic signals were associated with older age and male sex in a cohort with advanced carotid atherosclerosis. Symptomatic status was not a predictor for MES in this cohort, suggesting that plaques in both symptomatic and asymptomatic individuals have the ability to release microemboli, highlighting the need for further work to be done to identify unstable plaques.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15443167251347290","type":"journal-article","created":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T01:28:31Z","timestamp":1750469311000},"page":"93-99","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Risk Factors for Stroke and Associations With Microembolic Signals on Transcranial Doppler"],"prefix":"10.1177","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8469-1467","authenticated-orcid":false,"given":"Abdullah A.","family":"Adil","sequence":"first","affiliation":[{"name":"University of Michigan, Ann Arbor, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6445-3306","authenticated-orcid":false,"given":"Carol C.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health, Madison, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas D.","family":"Cook","sequence":"additional","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health, Madison, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenna","family":"Maybock","sequence":"additional","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health, Madison, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirvedh H.","family":"Meshram","sequence":"additional","affiliation":[{"name":"Advanced Micro Devices Inc, Santa Clara, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomy","family":"Varghese","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie M.","family":"Wilbrand","sequence":"additional","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health, Madison, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Dempsey","sequence":"additional","affiliation":[{"name":"University of Wisconsin School of Medicine and Public Health, Madison, 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