{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:10:21Z","timestamp":1777853421767,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2002,7,1]],"date-time":"2002-07-01T00:00:00Z","timestamp":1025481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the International Association of Physicians in AIDS Care"],"published-print":{"date-parts":[[2002,7]]},"abstract":"<jats:p>Muscular fatigue may result from HIV infection, and may be associated with antiretroviral drug treatment. Clinical features linked to muscle biopsy findings may assist in determining etiology, and guide treatment decisions.<\/jats:p>\n                  <jats:p>This case series examined HIV patients in an ambulatory HIV clinic who received antiretroviral therapy, and complained of unexplained muscular fatigue. Clinical features with measurement of acid-base status, levels of lactate, aminotransferases, triglycerides and creatine kinase were correlated to light and electron microscopic results of muscle biopsy.<\/jats:p>\n                  <jats:p>Three patients with acquired mitochondrial changes on biopsy shared common features of lactatemia, elevated aminotransferases and triglycerides, and ultrasonographic hepatic steatosis. A fourth patient with normal mitochondria had myositis with fibrosis, but no systemic symptoms. Biochemical parameters were unremarkable, except for a high creatine kinase.<\/jats:p>\n                  <jats:p>Acquired mitochondrial disease may manifest as systemic illness and muscular fatigue. Unique metabolic changes and other organ dysfunction may precede overt physical signs of HIV myopathy.<\/jats:p>","DOI":"10.1177\/154510970200100303","type":"journal-article","created":{"date-parts":[[2005,5,16]],"date-time":"2005-05-16T16:01:45Z","timestamp":1116259305000},"page":"90-94","source":"Crossref","is-referenced-by-count":2,"title":["Clinical Correlates to Muscle Biopsy Findings in HIV Patients Experiencing Fatigue: A case series"],"prefix":"10.1177","volume":"1","author":[{"given":"Steven C.","family":"Zell","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Health Care Research, University of Nevada School of Medicine, Reno, Nevada, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surl","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Sutter Medical Center, Sacramento, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,7,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199004193221602"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0595-417"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90112-3"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200002180-00001"},{"key":"atypb5","volume-title":"8th Conference on Retroviruses and Opportunistic Infections","author":"Vrouenraets SM"},{"key":"atypb6","volume-title":"8th Conference on Retroviruses and Opportunistic Infections","author":"Lonergan JT"},{"issue":"1","key":"atypb7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0889-857X(21)00092-2","volume":"17","author":"Espinoza LR","year":"1991","journal-title":"Rheum Dis Clin North Am"},{"issue":"2","key":"atypb8","first-page":"174","volume":"45","author":"Authier FJ","year":"1997","journal-title":"Arch Anat Cytol Pathol"},{"issue":"1","key":"atypb9","first-page":"5","volume":"86","author":"Peters BS","year":"1993","journal-title":"Q J Med"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-200002000-00002"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.12.2743"},{"key":"atypb12","volume-title":"39th Interscience Conference on Antimicrobial Agents and Chemotherapy","author":"Maulin L"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-3-200008010-00010"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.57.070188.002025"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)31547-3"},{"key":"atypb16","volume-title":"9th Conference on Retroviruses and Opportunistic Infections","author":"Birkus G"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199902040-00009"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200003100-00014"}],"container-title":["Journal of the International Association of Physicians in AIDS Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/154510970200100303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/154510970200100303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:52:29Z","timestamp":1777503149000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/154510970200100303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,7]]}},"alternative-id":["10.1177\/154510970200100303"],"URL":"https:\/\/doi.org\/10.1177\/154510970200100303","relation":{},"ISSN":["1545-1097"],"issn-type":[{"value":"1545-1097","type":"print"}],"subject":[],"published":{"date-parts":[[2002,7]]}}}