{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:10:07Z","timestamp":1777853407483,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T00:00:00Z","timestamp":1288569600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the International Association of Physicians in AIDS Care"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>\n                    Background: Although both tipranavir and darunavir are important options for the management of patients with multidrug resistant HIV, there are at present no studies comparing the effectiveness and safety of these 2 antiretroviral drugs in this population of patients. Objective: To compare the effectiveness and safety of ritonavir (TPV\/r)- and darunavir\/ritonavir (DRV\/ r)-based therapies in treatment-experienced patients (n = 38 and 47, respectively). Methods: Multicenter, retrospective cohort study. Results: The median baseline viral load and CD4 count were 4.7 copies\/mL (interquartile range [IQR] 4.3, 5.2) and 168 cells\/mm\n                    <jats:sup>3<\/jats:sup>\n                    (IQR 80, 252) for TPV\/r patients and 4.7 copies\/mL (IQR 3.7, 5.1) and 171 cells\/mm\n                    <jats:sup>3<\/jats:sup>\n                    (IQR 92, 290) for DRV\/r patients. The median number of years on antiretroviral therapy (ART) prior to starting DRV\/r or TPV\/r were 12.7 (10.2-15.5) and 10.5 (8.4-12.6), respectively (P &lt; .01). Current raltegravir (RAL) use (odds ratio [OR] 5.53, 95% CI 1.08-28.34) was significantly associated with virologic suppression at week 24 in multivariable logistic regression models, whereas the use of TPV\/r was not significantly associated with virologic suppression compared to DRV\/r (OR 0.93, 95% CI 0.27-3.18, P = .91). Conclusion: No significant difference was observed between DRV\/r and TPV\/r in terms of virologic suppression.\n                  <\/jats:p>","DOI":"10.1177\/1545109710382041","type":"journal-article","created":{"date-parts":[[2010,12,7]],"date-time":"2010-12-07T00:47:25Z","timestamp":1291682845000},"page":"382-389","source":"Crossref","is-referenced-by-count":2,"title":["Virologic and Immunologic Effectiveness of Tipranavir\/Ritonavir (TPV\/r)- Versus Darunavir\/Ritonavir (DRV\/r)-Based Regimens in Clinical Practice"],"prefix":"10.1177","volume":"9","author":[{"given":"Tony","family":"Antoniou","sequence":"first","affiliation":[{"name":"University of Toronto, Toronto, Ontario, Canada, Maple Leaf Medical Clinical, Toronto, Ontario, Canada, St Michael's Hospital, Toronto, Ontario, Canada,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Raboud","sequence":"additional","affiliation":[{"name":"University of Toronto, Toronto, Ontario, Canada, University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Diong","sequence":"additional","affiliation":[{"name":"University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Su","sequence":"additional","affiliation":[{"name":"University Health Network, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Dewhurst","sequence":"additional","affiliation":[{"name":"University of Toronto, Toronto, Ontario, Canada, St Michael's Hospital, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Buckley","sequence":"additional","affiliation":[{"name":"Maple Leaf Medical Clinical, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Kovacs","sequence":"additional","affiliation":[{"name":"University of Toronto, Toronto, 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