{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:42:08Z","timestamp":1790995328530,"version":"4.1.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2007,12,11]],"date-time":"2007-12-11T00:00:00Z","timestamp":1197331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p>Background. Electrical stimulation of damaged peripheral nerve may aid regeneration. Objective. The purpose of this study was to determine whether 1 mA of percutaneous electrical stimulation at 1, 2, 20, or 200 Hz augments regeneration between the proximal and distal nerve stumps. Methods. A10-mm gap was made in rat sciatic nerve by suturing the stumps into silicone rubber tubes. A control group received no stimulation. Starting 1 week after transection, electrical stimulation was applied between the cathode placed at the distal stump and the anode at the proximal stump every other day for 6 weeks. Results. Higher frequency stimulation led to less regeneration compared to lower frequencies. Quantitative histology of the successfully regenerated nerves revealed that the groups receiving electrical treatment, especially at 2 Hz, had a more mature structure with a smaller cross-sectional area, more myelinated fibers, higher axon density, and higher ratio of blood vessel to total nerve area compared with the controls. Electrophysiology showed significantly shorter latency, longer duration, and faster conduction velocity. Conclusion. Electrical stimulation can have either a positive or negative impact on peripheral nerve regeneration. Clinical trials that combine stimulation with rehabilitation must determine the parameters that are most likely to be safe and effective.<\/jats:p>","DOI":"10.1177\/1545968307313507","type":"journal-article","created":{"date-parts":[[2008,7,28]],"date-time":"2008-07-28T17:56:02Z","timestamp":1217267762000},"page":"367-373","source":"Crossref","is-referenced-by-count":119,"title":["Effects of Electrical Stimulation at Different Frequencies on Regeneration of Transected Peripheral Nerve"],"prefix":"10.1177","volume":"22","author":[{"given":"Ming-Chin","family":"Lu","sequence":"first","affiliation":[{"name":"School of Post Baccalaureate Chinese Medicine, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Yi","family":"Ho","sequence":"additional","affiliation":[{"name":"Laboratory of Biomaterials, Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Feng","family":"Hsu","sequence":"additional","affiliation":[{"name":"School of Chinese Medicine, China Medical University, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Chung","family":"Lee","sequence":"additional","affiliation":[{"name":"Graduate Institute of Integration and Western Medicine, China Medical University, Taichung, Taiwan, Division of Neurosurgery, China Medical University Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Horng","family":"Lin","sequence":"additional","affiliation":[{"name":"Laboratory of Fiber Application and Manufacturing, Graduated Institute of Textile Engineering, Feng Chia University, Taichung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hsu","family":"Yao","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering and Material Science, Central Taiwan University of Science and Technology, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueh-Sheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Biomaterials, Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2007,12,11]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.200600257"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.20050"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2004.09.060"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.12.029"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20582"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2003.99.3.0555"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1594.2007.00335.x"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2006-0011"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00451.2001"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1023\/B:CEMN.0000022770.66463.f7"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-006-1058-0"},{"key":"atypb12","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2006.105.4.610"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000071289.11767.22"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199910)22:10<1393::AID-MUS9>3.0.CO;2-E"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9993(96)90160-4"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X99000343"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2007.01.040"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20339"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.200500151"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(92)90112-4"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/71.5.397"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1016\/0026-2862(87)90015-X"},{"key":"atypb23","doi-asserted-by":"publisher","DOI":"10.1016\/0026-2862(90)90003-A"},{"key":"atypb24","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90645-X"},{"key":"atypb25","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/66.6.937"},{"key":"atypb26","doi-asserted-by":"publisher","DOI":"10.3109\/09638289809166052"},{"key":"atypb27","doi-asserted-by":"publisher","DOI":"10.2519\/jospt.1993.18.3.488"},{"key":"atypb28","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1972.223.1.138"}],"container-title":["Neurorehabilitation and Neural Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1545968307313507","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1545968307313507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:01:56Z","timestamp":1777705316000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1545968307313507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,11]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1177\/1545968307313507"],"URL":"https:\/\/doi.org\/10.1177\/1545968307313507","relation":{},"ISSN":["1545-9683","1552-6844"],"issn-type":[{"value":"1545-9683","type":"print"},{"value":"1552-6844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,11]]}}}