{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:26:55Z","timestamp":1790508415301,"version":"4.1.0"},"reference-count":26,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2010,7,26]],"date-time":"2010-07-26T00:00:00Z","timestamp":1280102400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:p>Background: Autologous bone marrow mesenchymal cells that include stem cells (MSCs) are a clinically attractive cellular therapy option to try to treat severe spinal cord injury (SCI). Objective: To study the possible value of MSCs injected intrathecally to enhance rehabilitation. Methods: This case control, convenience sample included 64 patients, at a mean of 3.6 years after SCI. Forty-four subjects received monthly intrathecal autologous MSCs for 6 months and 20 subjects, who would not agree to the procedures, served as controls. All subjects received rehabilitation therapies 3 times weekly. Subjects were evaluated at entry and at 12 months after completing the 6-months intervention. By the ASIA Impairment Scale, ASIA grading of completeness of injury, Ashworth Spasticity Scale, Functional Ambulation Classification, and bladder and bowel control questionnaire. Results: No differences were found in baseline measures and descriptors between the MSC group and control group. Although a higher percentage of the MSC group increased motor scores by 1-2 points and changed from ASIA A to B, no significant between-group improvements were found in clinical measures. Adverse effects of cells included spasticity and, in 24 out of the 43 patients developed neuropathic pain. One subject with a history of post-infectious myelitis developed encephalomyelitis after her third injection. Conclusion: Autologus MSCs may have side effects and may be contraindicated in patients with a history of myelitis. Their utility in treating chronic traumatic SCI needs further study in pre-clinical models and in randomized controlled trials before they should be offered to patients.<\/jats:p>","DOI":"10.1177\/1545968310369801","type":"journal-article","created":{"date-parts":[[2010,7,26]],"date-time":"2010-07-26T23:17:45Z","timestamp":1280186265000},"page":"702-708","source":"Crossref","is-referenced-by-count":135,"title":["Case Control Series of Intrathecal Autologous Bone Marrow Mesenchymal Stem Cell Therapy for Chronic Spinal Cord Injury"],"prefix":"10.1177","volume":"24","author":[{"given":"Nirmeen A.","family":"Kishk","sequence":"first","affiliation":[{"name":"Department of Neurology, Cairo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala","family":"Gabr","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Cairo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif","family":"Hamdy","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cairo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamia","family":"Afifi","sequence":"additional","affiliation":[{"name":"Clinical Neurophysiology Unit, Cairo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha","family":"Abokresha","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cairo University,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayam","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Physical Medicine, Cairo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Wafaie","sequence":"additional","affiliation":[{"name":"Department of Radiology, Cairo University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia","family":"Bilal","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, National Cancer Institute, Cairo University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2010,7,26]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(01)00774-2"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968309347685"},{"key":"atypb3","doi-asserted-by":"publisher","DOI":"10.1038\/nature00870"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1038\/nm886"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.8039"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5497.1779"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2006.23.55"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2007.0083"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5497.1775"},{"key":"atypb10","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21617"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-15-06623.2002"},{"key":"atypb12","volume-title":"Paper presented at the American Occupational Therapy Association Annual Conference","author":"Levit K."},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(76)90113-5"},{"key":"atypb14","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/67.2.206"},{"key":"atypb15","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/66.10.1530"},{"key":"atypb16","volume-title":"Standard for Neurological Classification of Spinal Injury Patients","author":"American Spinal Injury Association.","year":"1984"},{"key":"atypb17","unstructured":"Mahoney FI, Barthel DW Functional evaluation: The Barthel Index. 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