{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:18:23Z","timestamp":1790713103280,"version":"4.1.0"},"reference-count":44,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2014,2,11]],"date-time":"2014-02-11T00:00:00Z","timestamp":1392076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Background.<\/jats:italic>\n                    Prognosis of long-term motor outcome of acute stroke patients with severe motor impairment is difficult to determine.\n                    <jats:italic toggle=\"yes\">Objective<\/jats:italic>\n                    . Our primary goal was to evaluate the prognostic value of corticospinal tract (CST) injury on motor outcome of the upper limb compared with motor impairment level and lesion volume.\n                    <jats:italic toggle=\"yes\">Methods.<\/jats:italic>\n                    In all, 10 acute stroke patients with moderately severe to severe motor impairment of the upper limb underwent diffusion tensor imaging (DTI) and testing of upper limb strength and dexterity at acute, subacute, and chronic poststroke time points. A density-weighted CST atlas was constructed using DTI tractography data from normal participants. This CST atlas was applied, using a largely automated process, to DTI data from patients to quantify CST injury at each time point. Differences in axial diffusivity (AD), radial diffusivity (RD), and fractional anisotropy (FA) of the ipsilesional CST relative to the contralesional CST were measured.\n                    <jats:italic toggle=\"yes\">Results.<\/jats:italic>\n                    Acute loss in CST AD correlated most strongly and significantly with subacute and chronic strength and dexterity and remained significant after adjusting for acute motor impairment or lesion volume. Subacute loss in CST FA correlated most strongly with chronic dexterity, whereas subacute behavioral measures of limb strength correlated most strongly with chronic strength measures.\n                    <jats:italic toggle=\"yes\">Conclusions.<\/jats:italic>\n                    Loss in acute CST AD and subacute CST FA are strong prognostic indicators of future motor functions of the upper limb for stroke patients with substantial initial motor impairment. DTI-derived measure of CST injury early after stroke may have utility in health care planning and in design of acute stroke clinical trials.\n                  <\/jats:p>","DOI":"10.1177\/1545968314521896","type":"journal-article","created":{"date-parts":[[2014,2,11]],"date-time":"2014-02-11T22:32:23Z","timestamp":1392157943000},"page":"751-760","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":99,"title":["Corticospinal Tract Diffusion Abnormalities Early After Stroke Predict Motor Outcome"],"prefix":"10.1177","volume":"28","author":[{"given":"Benjamin N.","family":"Groisser","sequence":"first","affiliation":[{"name":"MGH\/HST Athinoula A. 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