{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:21:35Z","timestamp":1791246095185,"version":"4.1.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,8,4]],"date-time":"2014-08-04T00:00:00Z","timestamp":1407110400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>\n                    Background. The contribution of lesion size and location in poststroke aphasia is debated, especially the extent to which aphasia severity is affected by damage to specific white matter areas. Objective. To identify specific white matter areas critical for poststroke aphasia global severity and to determine whether injury to these areas had more impact on aphasia severity than the infarct volume. Methods. Twenty-three chronic poststroke aphasic patients were assessed with the Aphasia Rapid Test (ART) and the Boston Diagnosis Aphasia Examination (BDAE) global severity scales and underwent diffusion tensor and structural imaging. Voxel-based diffusion tensor imaging regression analysis was used to determine in which areas fractional anisotropy (FA) abnormalities were correlated with ART and BDAE severity scales. The relationships between aphasia severity, FA values, and infarct volumes were investigated using global and partial correlations. Results. We found a critical area associated with aphasia severity overlapping with the arcuate and the inferior fronto-occipital fasciculi, resulting in a combined disconnection of the dorsal and ventral pathways. ART scores were inversely correlated with FA values in this region, with greater severity present with lower FA values (correlation coefficient = \u22120.833, P &lt; .0001). The proportion of variance explained by the FA value was higher than the proportion of variance explained by the infarct volume ( R\n                    <jats:sup>2<\/jats:sup>\n                    = 68% vs 27%, P = .01). The impact of infarct volume on aphasia severity disappeared when damage to this critical white matter area was taken into account ( P = .38). Conclusion. The assessment of the integrity of this region may potentially have a clinical impact in neurorehabilitation and acute decision making.\n                  <\/jats:p>","DOI":"10.1177\/1545968314543926","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T20:33:35Z","timestamp":1407270815000},"page":"287-295","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":41,"title":["Aphasia Severity in Chronic Stroke Patients"],"prefix":"10.1177","volume":"29","author":[{"given":"Charlotte","family":"Rosso","sequence":"first","affiliation":[{"name":"CRICM\u2013Centre de Recherche de l\u2019Institut du Cerveau et de la Moelle \u00e9pini\u00e8re, Paris, France"},{"name":"INSERM, U1127; CNRS, UMR 7225, Paris, France"},{"name":"COGIMAGE, Paris, France"},{"name":"APHP, Service des Urgences C\u00e9r\u00e9bro-Vasculaires, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"},{"name":"Univ Paris 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Arbizu","sequence":"additional","affiliation":[{"name":"APHP, Service des Urgences C\u00e9r\u00e9bro-Vasculaires, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"},{"name":"Centre des maladies cognitives et comportementales, IM2A, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Henry-Amar","sequence":"additional","affiliation":[{"name":"APHP, Service des Urgences C\u00e9r\u00e9bro-Vasculaires, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"},{"name":"Centre des maladies cognitives et comportementales, IM2A, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Leger","sequence":"additional","affiliation":[{"name":"APHP, Service des Urgences C\u00e9r\u00e9bro-Vasculaires, 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