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Pepper Older Americans Independence Center","award":["P30-AG013679"],"award-info":[{"award-number":["P30-AG013679"]}]},{"name":"Harvard Catalyst | The Harvard Clinical and Translational Science Center","award":["UL1 RR025758"],"award-info":[{"award-number":["UL1 RR025758"]}]},{"DOI":"10.13039\/100008590","name":"Dr. Ralph and Marian Falk Medical Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008590","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:p>Objective. To determine the effects of a transcranial direct current stimulation (tDCS) intervention with the anode placed over the left dorsolateral prefrontal cortex (dlPFC) and cathode over the right supraorbital region, on cognition, mobility, and \u201cdual-task\u201d standing and walking in older adults with mild-to-moderate motor and cognitive impairments. Methods. A double-blinded, block-randomized, sham-controlled trial was conducted in 18 nondemented, ambulatory adults aged \u2a7e65 years with slow walking speed (\u2a7d1.0 m\/s) and \u201cexecutive\u201d dysfunction (Trail Making Test B score \u2a7d25th percentile of age- and education-matched norms). Interventions included ten 20-minute sessions of tDCS or sham stimulation. Cognition, mobility, and dual-task standing and walking were assessed at baseline, postintervention, and 2 weeks thereafter. Dual tasking was also assessed immediately before and after the first tDCS session. Results. Intervention compliance was high (mean \u00b1 SD = 9.5 \u00b1 1.1 sessions) and no unexpected or serious side effects were reported. tDCS, compared with sham, induced improvements in the Montreal Cognitive Assessment total score ( P = .03) and specifically within the executive function subscore of this test ( P = .002), and in several metrics of dual-task standing and walking ( P &lt; .05). Each of these effects persisted for 2 weeks. tDCS had no effect on the Timed Up-and-Go test of mobility or the Geriatric Depression Scale. Those participants who exhibited larger improvements in dual-task standing posture following the first tDCS session exhibited larger cognitive-motor improvements following 2 weeks of tDCS ( P &lt; .04). Interpretation. tDCS intervention designed to stimulate the left dorsolateral prefrontal cortex may improve executive function and dual tasking in older adults with functional limitations.<\/jats:p>","DOI":"10.1177\/1545968318792616","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T07:17:38Z","timestamp":1534922258000},"page":"788-798","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":89,"title":["Transcranial Direct Current Stimulation May Improve Cognitive-Motor Function           in Functionally Limited Older Adults"],"prefix":"10.1177","volume":"32","author":[{"given":"Brad","family":"Manor","sequence":"first","affiliation":[{"name":"Institute for Aging Research, Hebrew\r        SeniorLife, Roslindale, MA, USA"},{"name":"Beth Israel Deaconess Medical Center, Boston,\r        MA, USA"},{"name":"Harvard Medical School, Boston, MA, 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