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Subcortical infarcts can result in verbal memory impairment, but the potential underlying mechanisms remain unknown. Objective. We investigated the spatiotemporal deterioration patterns of brain structures in patients with subcortical infarction and identified the regions that contributed to verbal memory impairment. Methods. Cognitive assessment and structural magnetic resonance imaging were performed 1, 4, and 12 weeks after stroke onset in 28 left-hemisphere and 22 right-hemisphere stroke patients with subcortical infarction. Whole-brain volumetric analysis combined with a further-refined shape analysis was conducted to analyze longitudinal morphometric changes in brain structures and their relationship to verbal memory performance. Results. Between weeks 1 and 12, significant volume decreases in the ipsilesional basal ganglia, inferior white matter, and thalamus were found in the left-hemisphere stroke group. Among those 3 structures, only the change rate of the thalamus volume was significantly correlated with that in immediate recall. For the right-hemisphere stroke group, only the ipsilesional basal ganglia survived the week 1 to week 12 group comparison, but its change rate was not significantly correlated with the verbal memory change rate. Shape analysis of the thalamus revealed atrophies of the ipsilesional thalamic subregions connected to the prefrontal, temporal, and premotor cortices in the left-hemisphere stroke group and positive correlations between the rates of those atrophies and the change rate in immediate recall. Conclusions. Secondary damage to the thalamus, especially to the left subregions connected to specific cortices, may be associated with early verbal memory impairment following an acute subcortical infarct.<\/jats:p>","DOI":"10.1177\/1545968319846121","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T02:33:23Z","timestamp":1557714803000},"page":"476-485","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Regional Shape Abnormalities in Thalamus and Verbal Memory Impairment After Subcortical Infarction"],"prefix":"10.1177","volume":"33","author":[{"given":"Gang","family":"Liu","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital, Sun Yat\u2013Sen University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Tan","sequence":"additional","affiliation":[{"name":"Southern University of Science and Technology, Shenzhen, Guangdong, China"},{"name":"Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Dang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Sun Yat\u2013Sen University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangquan","family":"Tan","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Sun Yat\u2013Sen University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihui","family":"Xing","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Sun Yat\u2013Sen University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianwei","family":"Huang","sequence":"additional","affiliation":[{"name":"Southern University of Science and Technology, 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