{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:00:27Z","timestamp":1777942827101,"version":"3.51.4"},"reference-count":74,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001711","name":"schweizerischer nationalfonds zur f\u00f6rderung der wissenschaftlichen forschung","doi-asserted-by":"publisher","award":["Grant Nos 31-61857.00, 310000- 110005, 31003A-1324"],"award-info":[{"award-number":["Grant Nos 31-61857.00, 310000- 110005, 31003A-1324"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Background<\/jats:italic>\n                    . Autologous neural cell ecosystem (ANCE) transplantation improves motor recovery in MPTP monkeys. These motor symptoms were assessed using semi-quantitative clinical rating scales, widely used in many studies. However, limitations in terms of sensitivity, combined with relatively subjective assessment of their different items, make inter-study comparisons difficult to achieve.\n                    <jats:italic toggle=\"yes\">Objective<\/jats:italic>\n                    . The aim of this study was to quantify the impact of MPTP intoxication in macaque monkeys on manual dexterity and assess whether ANCE can contribute to functional recovery.\n                    <jats:italic toggle=\"yes\">Methods<\/jats:italic>\n                    . Four animals were trained to perform 2 manual dexterity tasks. After reaching a motor performance plateau, the animals were subjected to an MPTP lesion. After the occurrence of a spontaneous functional recovery plateau, all 4 animals were subjected to ANCE transplantation.\n                    <jats:italic toggle=\"yes\">Results<\/jats:italic>\n                    . Two of 4 animals underwent a full spontaneous recovery before the ANCE transplantation, whereas the 2 other animals (symptomatic) presented moderate to severe Parkinson\u2019s disease (PD)-like symptoms affecting manual dexterity. The time to grasp small objects using the precision grip increased in these 2 animals. After ANCE transplantation, the 2 symptomatic animals underwent a significant functional recovery, reflected by a decrease in time to execute the different tasks, as compared with the post-lesion phase.\n                    <jats:italic toggle=\"yes\">Conclusions<\/jats:italic>\n                    . Manual dexterity is affected in symptomatic MPTP monkeys. The 2 manual dexterity tasks reported here as pilot are pertinent to quantify PD symptoms and reliably assess a treatment in MPTP monkeys, such as the present ANCE transplantation, to be confirmed in a larger cohort of animals before future clinical applications.\n                  <\/jats:p>","DOI":"10.1177\/1545968319850133","type":"journal-article","created":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T02:30:42Z","timestamp":1559874642000},"page":"553-567","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Fine Manual Dexterity Assessment After Autologous Neural Cell Ecosystem (ANCE) Transplantation in a Non-human Primate Model of Parkinson\u2019s Disease"],"prefix":"10.1177","volume":"33","author":[{"given":"Simon","family":"Borgognon","sequence":"first","affiliation":[{"name":"University of Fribourg, Fribourg, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Cottet","sequence":"additional","affiliation":[{"name":"University of Fribourg, Fribourg, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Moret","sequence":"additional","affiliation":[{"name":"University of Fribourg, Fribourg, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Chatagny","sequence":"additional","affiliation":[{"name":"University of Fribourg, Fribourg, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Carrara","sequence":"additional","affiliation":[{"name":"University of Fribourg, Fribourg, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Fregosi","sequence":"additional","affiliation":[{"name":"University of Fribourg, Fribourg, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyne","family":"Bloch","sequence":"additional","affiliation":[{"name":"Lausanne University Hospital (CHUV), Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Brunet","sequence":"additional","affiliation":[{"name":"Lausanne University Hospital (CHUV), Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1355-6019","authenticated-orcid":false,"given":"Eric M.","family":"Rouiller","sequence":"additional","affiliation":[{"name":"University of Fribourg, Fribourg, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Badoud","sequence":"additional","affiliation":[{"name":"University of Fribourg, Fribourg, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,6,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.427"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0922-4106(91)90073-Q"},{"key":"e_1_3_3_4_2","first-page":"600","article-title":"Similarities and differences between MPTP-induced parkinsonism and Parkinson\u2019s disease: neuropathologic considerations","volume":"60","author":"Forno LS","year":"1993","unstructured":"Forno LS, DeLanney LE, Irwin I, Langston JW. 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