{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:44:57Z","timestamp":1793724297624,"version":"4.6.1"},"reference-count":46,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:00:00Z","timestamp":1583280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:p>\n                    <jats:italic toggle=\"yes\">Background<\/jats:italic>\n                    . In the general population, trajectories of walking capacity is accelerated and nonlinear with advanced age. Whether this is more pronounced in persons with multiple sclerosis (pwMS), along with the prevalence of dismobility (ie, slow gait speed), are currently unknown. Our objective was to investigate trajectories of walking capacity and prevalence of dismobility across the adult life span in pwMS versus healthy controls (HC).\n                    <jats:italic toggle=\"yes\">Methods<\/jats:italic>\n                    . Data on maximal timed 25-foot walk test (T25FWT), 2-minute walk test (2MWT), and 6-minute walk test (6MWT) along with prevalence of dismobility were assembled from 2 RIMS multicenter studies (n = 502 pwMS; age range 21-77 years, 6 age groups: 20-29, 30-39, 40-49, 50-59, 60-69, and 70-79 years). HC data were extracted from studies containing normative reference values (n = 1070-3780 HC).\n                    <jats:italic toggle=\"yes\">Results<\/jats:italic>\n                    . Age trajectories of walking capacity was nonlinear and accelerated in pwMS versus HC. While measures of walking capacity in pwMS were suppressed already early in life, the gap between pwMS and HC significantly widened across the 6 age groups (pwMS performed 64%, 70%, 57%, 59%, 51%, and 37% of HC, respectively). This coincided with high prevalences of dismobility in pwMS across the 6 age groups when using usual gait speed cut-point values &lt;1.0 m\/s (corresponding to 33%, 32%, 51%, 59%, 75%, and 100%) and &lt;0.6 m\/s (corresponding to 19%, 12%, 26%, 23%, 33%, and 43%), markedly exceeding that observed in HC.\n                    <jats:italic toggle=\"yes\">Conclusion<\/jats:italic>\n                    . The present data on walking capacity provide evidence for an accelerated deterioration in pwMS with advanced age, coinciding with high prevalences of dismobility (ie, slow gait speed).\n                  <\/jats:p>","DOI":"10.1177\/1545968320907074","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T03:51:52Z","timestamp":1583293912000},"page":"360-369","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Accelerated Trajectories of Walking Capacity Across the Adult Life Span in Persons With Multiple Sclerosis: An Underrecognized Challenge"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3233-0429","authenticated-orcid":false,"given":"Lars G.","family":"Hvid","sequence":"first","affiliation":[{"name":"Department Public Health, Section of Sport Science, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5680-5495","authenticated-orcid":false,"given":"Peter","family":"Feys","sequence":"additional","affiliation":[{"name":"REVAL - Rehabilitation Research Research Center\u2014BIOMED, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"Baert","sequence":"additional","affiliation":[{"name":"REVAL - Rehabilitation Research Research Center\u2014BIOMED, Biomedical Research Institute, Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alon","family":"Kalron","sequence":"additional","affiliation":[{"name":"Sackler Faculty of Medicine and Sagol School of Neurosciences, Tel-Aviv University, Tel-Aviv, Israel"},{"name":"Sheba Multiple Sclerosis Center, Tel-Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrik","family":"Dalgas","sequence":"additional","affiliation":[{"name":"Department Public Health, Section of Sport Science, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,3,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2013-305450"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318230a17d"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2016-315238"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000695"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.24095\/hpcdp.37.2.02"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007035"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glw043"},{"key":"e_1_3_3_9_2","first-page":"1135","article-title":"Trajectories of function and biomarkers with age: the CHS All Stars Study","volume":"45","author":"Newman AB","year":"2016","unstructured":"Newman AB, Sanders JL, Kizer JR, et al. Trajectories of function and biomarkers with age: the CHS All Stars Study. Int J Epidemiol. 2016;45:1135-1145.","journal-title":"Int J Epidemiol"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000000731"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k1046"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acp076"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458516679036"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2015.02.003"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/107937390703000306"},{"key":"e_1_3_3_16_2","first-page":"205521731772830","article-title":"Which symptoms contribute the most to patients\u2019 perception of health in multiple sclerosis?","volume":"3","author":"Green R","year":"2017","unstructured":"Green R, Cutter G, Friendly M, Kister I. Which symptoms contribute the most to patients\u2019 perception of health in multiple sclerosis? Mult Scler J. 2017;3:2055217317728301.","journal-title":"Mult Scler J"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.7224\/1537-2073.2015-006"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.01.001"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.7224\/1537-2073-13.1.4"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968315597070"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.3033"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1923"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53501.x"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13442"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968314521010"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511420598"},{"key":"e_1_3_3_27_2","first-page":"207","article-title":"Walking capacity and ability are more impaired in progressive compared to relapsing type of multiple sclerosis","volume":"51","author":"Feys P","year":"2015","unstructured":"Feys P, Bibby BM, Baert I, Dalgas U. Walking capacity and ability are more impaired in progressive compared to relapsing type of multiple sclerosis. Eur J Phys Rehabil Med. 2015;51:207-210.","journal-title":"Eur J Phys Rehabil Med"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/26.1.15"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2018.06.031"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1589\/jpts.29.2224"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003847"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2014.02.016"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-009-0246-z"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458518790397"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12625"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002702"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003542"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2016.07.003"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000560"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0183-3"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-019-03875-7"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00577"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-019-1002-3"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181bf98b4"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968308320641"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2016.03.018"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2017.06.003"}],"container-title":["Neurorehabilitation and Neural Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1545968320907074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1545968320907074","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1545968320907074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:08:22Z","timestamp":1777705702000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1545968320907074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,4]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1177\/1545968320907074"],"URL":"https:\/\/doi.org\/10.1177\/1545968320907074","relation":{},"ISSN":["1545-9683","1552-6844"],"issn-type":[{"value":"1545-9683","type":"print"},{"value":"1552-6844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,4]]}}}