{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T02:44:48Z","timestamp":1793501088746,"version":"4.5.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T00:00:00Z","timestamp":1591488000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:p>Spinal cord injury results in devastating neurological deficits accompanied by lifelong disability and significant economic burden. While the development of novel compounds or cell-based interventions for spinal cord injury is unquestionably worthwhile, a complementary approach examines current standards of care and the degree to which these can be optimized to benefit long-term neurological function. Numerous classes of drugs, already in use in the acute phase of spinal cord injury, are intriguing because they (1) readily cross the blood-spinal cord barrier to modulate activity in the central nervous system and (2) are administered during a window of time in which neuroprotection, and even some repair, are feasible. Here, we review a rare case of convergent lines of evidence from both preclinical and human studies to support the early administration of a class of drug (ie, gabapentinoids) to both foster motor recovery and reduce the severity of neuropathic pain.<\/jats:p>","DOI":"10.1177\/1545968320931516","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T02:35:18Z","timestamp":1591583718000},"page":"686-689","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Beneficial \u201cPharmaceutical Pleiotropy\u201d of Gabapentinoids in Spinal Cord Injury: A Case for Refining Standard-of-Care"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6284-938X","authenticated-orcid":false,"given":"Jacquelyn J.","family":"Cragg","sequence":"first","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine R.","family":"Jutzeler","sequence":"additional","affiliation":[{"name":"ETH Zurich, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Grassner","sequence":"additional","affiliation":[{"name":"Paracelsus Medical University, Salzburg, Austria"},{"name":"Medical University Innsbruck, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Ramer","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Bradke","sequence":"additional","affiliation":[{"name":"German Centre for Neurodegenerative Disease (DZNE), Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John L. K.","family":"Kramer","sequence":"additional","affiliation":[{"name":"International Collaboration on Repair Discoveries (ICORD), Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,7]]},"reference":[{"key":"bibr1-1545968320931516","doi-asserted-by":"publisher","DOI":"10.24095\/hpcdp.33.3.01"},{"key":"bibr2-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032037"},{"key":"bibr3-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004519"},{"key":"bibr4-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70144-9"},{"key":"bibr5-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-200109000-00002"},{"key":"bibr6-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70251-0"},{"key":"bibr7-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000244422.45278.ff"},{"key":"bibr8-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318281546b"},{"key":"bibr9-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.09.026"},{"key":"bibr10-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1097\/AAP.0b013e3181fa6b7a"},{"key":"bibr11-1545968320931516","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-2105"},{"key":"bibr12-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6494-11.2012"},{"key":"bibr13-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.09.025"},{"key":"bibr14-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1038\/nature11059"},{"key":"bibr15-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.003591"},{"key":"bibr16-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.723478"},{"key":"bibr17-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.12.007"},{"key":"bibr18-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.5960"},{"key":"bibr19-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1177\/1545968315624777"},{"key":"bibr20-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-019-00622-6"},{"key":"bibr21-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.01.048"},{"key":"bibr22-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1172\/JCI130391"},{"key":"bibr23-1545968320931516","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2011.26.3.404"},{"key":"bibr24-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2010.04.008"},{"key":"bibr25-1545968320931516","doi-asserted-by":"publisher","DOI":"10.3171\/2011.4.SPINE10583"},{"key":"bibr26-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0316-17.2017"},{"key":"bibr27-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e318249d36e"},{"key":"bibr28-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000000749"},{"key":"bibr29-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2004.01.004"},{"key":"bibr30-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20627"},{"key":"bibr31-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1097\/00045391-200205000-00005"},{"key":"bibr32-1545968320931516","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-52137-8.00038-3"}],"container-title":["Neurorehabilitation and Neural Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1545968320931516","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1545968320931516","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1545968320931516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:08:30Z","timestamp":1777705710000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1545968320931516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,7]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1177\/1545968320931516"],"URL":"https:\/\/doi.org\/10.1177\/1545968320931516","relation":{},"ISSN":["1545-9683","1552-6844"],"issn-type":[{"value":"1545-9683","type":"print"},{"value":"1552-6844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,7]]}}}