{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T15:53:03Z","timestamp":1793980383138,"version":"4.8.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T00:00:00Z","timestamp":1605484800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The framework of ERA-NET NEURON","award":["BMBF, 01EW1711A and B"],"award-info":[{"award-number":["BMBF, 01EW1711A and B"]}]},{"name":"The EU project","award":["\u2018NISCI\u2019 grant agreement no. 681094"],"award-info":[{"award-number":["\u2018NISCI\u2019 grant agreement no. 681094"]}]},{"name":"The International Foundation for Research in Paraplegia","award":["IRP-P158"],"award-info":[{"award-number":["IRP-P158"]}]},{"name":"SNF Eccellenza Professorial Fellowship grant","award":["PCEFP3_181362 \/ 1"],"award-info":[{"award-number":["PCEFP3_181362 \/ 1"]}]},{"DOI":"10.13039\/100008191","name":"Wings for Life","doi-asserted-by":"publisher","award":["WFL-CH-007\/14"],"award-info":[{"award-number":["WFL-CH-007\/14"]}],"id":[{"id":"10.13039\/100008191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["091593\/Z\/10\/Z"],"award-info":[{"award-number":["091593\/Z\/10\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The majority of patients with spinal cord injury (SCI) have anatomically incomplete lesions and present with preserved tissue bridges, yet their outcomes vary.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the predictive value of the anatomical location (ventral\/dorsal) and width of preserved midsagittal tissue bridges for American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade conversion and SCI patient stratification into recovery-specific subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective longitudinal study includes 70 patients (56 men, age: 52.36 \u00b1 18.58 years) with subacute (ie, 1 month) SCI (45 tetraplegics, 25 paraplegics), 1-month neuroimaging data, and 1-month and 12-month clinical data. One-month midsagittal T2-weighted scans were used to determine the location and width of tissue bridges. Their associations with functional outcomes were assessed using partial correlation and unbiased recursive partitioning conditional inference tree (URP-CTREE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty-seven (81.4%) of 70 patients had tissue bridges (2.53 \u00b1 2.04 mm) at 1-month post-SCI. Larger ventral ( P = .001, r = 0.511) and dorsal ( P &lt; .001, r = 0.546) tissue bridges were associated with higher AIS conversion rates 12 months post-SCI (n = 39). URP-CTREE analysis identified 1-month ventral tissue bridges as predictors of 12-month total motor scores (0.4 mm cutoff, P = .008), recovery of upper extremity motor scores at 12 months (1.82 mm cutoff, P = .002), 12-month pin-prick scores (1.4 mm cutoff, P = .018), and dorsal tissue bridges at 1 month as predictors of 12-month Spinal Cord Independence Measure scores (0.5 mm cutoff, P = .003).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Midsagittal tissue bridges add predictive value to baseline clinical measures for post-SCI recovery. Based on tissue bridges\u2019 width, patients can be classified into subgroups of clinical recovery profiles. Midsagittal tissue bridges provide means to optimize patient stratification in clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1545968320971787","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T04:52:27Z","timestamp":1605502347000},"page":"33-43","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":48,"title":["Predictive Value of Midsagittal Tissue Bridges on Functional Recovery After Spinal Cord Injury"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2406-9251","authenticated-orcid":false,"given":"Dario","family":"Pfyffer","sequence":"first","affiliation":[{"name":"Balgrist University Hospital, University of Zurich, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Vallotton","sequence":"additional","affiliation":[{"name":"Balgrist University Hospital, University of 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