{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:35:56Z","timestamp":1792787756421,"version":"4.5.0"},"reference-count":60,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672253"],"award-info":[{"award-number":["81672253"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902309"],"award-info":[{"award-number":["81902309"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018479","name":"Guangzhou Institute of Pediatrics","doi-asserted-by":"crossref","award":["GCP-2018-007"],"award-info":[{"award-number":["GCP-2018-007"]}],"id":[{"id":"10.13039\/100018479","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100018479","name":"Guangzhou Institute of Pediatrics","doi-asserted-by":"crossref","award":["YIP-2018-014"],"award-info":[{"award-number":["YIP-2018-014"]}],"id":[{"id":"10.13039\/100018479","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100018479","name":"Guangzhou Institute of Pediatrics","doi-asserted-by":"crossref","award":["YIP-2019-015"],"award-info":[{"award-number":["YIP-2019-015"]}],"id":[{"id":"10.13039\/100018479","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515010420"],"award-info":[{"award-number":["2019A1515010420"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Featured Clinical Technique Foundation of Guangzhou","award":["2019TS55"],"award-info":[{"award-number":["2019TS55"]}]},{"name":"The Science Technology and Innovation Development Foundation of Guangzhou","award":["GWCMC2020LH-1-004"],"award-info":[{"award-number":["GWCMC2020LH-1-004"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:p>Background. Little is known about the induction of functional and brain structural reorganization in hemiplegic cerebral palsy (HCP) by constraint-induced movement therapy (CIMT). Objective. We aimed to explore the specific molecular mechanism of functional and structural plasticity related to CIMT in HCP. Methods. The mice were divided into a control group and HCP groups with different interventions (unconstraint-induced movement therapy [UNCIMT], CIMT or siRNA-Nogo-A [SN] treatment): the HCP, HCP+UNCIMT, HCP+CIMT, HCP+SN, and HCP+SN+CIMT groups. Rotarod and front-limb suspension tests, immunohistochemistry, Golgi-Cox staining, transmission electron microscopy, and Western blot analyses were applied to measure motor function, neurons and neurofilament density, dendrites\/axon areas, myelin integrity, and Nogo-A\/NgR\/RhoA\/ROCK expression in the motor cortex. Results. The mice in the HCP+CIMT group had better motor function, greater neurons and neurofilament density, dendrites\/axon areas, myelin integrity, and lower Nogo-A\/NgR\/RhoA\/ROCK expression in the motor cortex than the HCP and HCP+UNCIMT groups ( P &lt; .05). Moreover, the expression of Nogo-A\/NgR\/RhoA\/ROCK, the improvement of neural remodeling and motor function of mice in the HCP+SN group were similar to those in the HCP+CIMT group ( P &gt; .05). The neural remodeling and motor function of the HCP+SN+CIMT group were significantly greater than those in the HCP+SN and HCP+CIMT groups ( P &lt; .05). Motor function were positively correlated with the density of neurons ( r = 0.450 and 0.309, respectively; P &lt; .05) and neurofilament ( r = 0.717 and 0.567, respectively; P &lt; .05). Conclusions. CIMT might promote the remodeling of neurons, neurofilament, dendrites\/axon areas, and myelin in the motor cortex by partially inhibiting the Nogo-A\/NgR\/RhoA\/ROCK pathway, thereby promoting the improvement of motor function in HCP mice.<\/jats:p>","DOI":"10.1177\/1545968320981962","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T19:02:46Z","timestamp":1610564566000},"page":"145-157","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Constraint-Induced Movement Therapy Promotes Neural Remodeling and Functional Reorganization by Overcoming Nogo-A\/NgR\/RhoA\/ROCK Signals in Hemiplegic Cerebral Palsy Mice"],"prefix":"10.1177","volume":"35","author":[{"given":"Li-Ru","family":"Liu","sequence":"first","affiliation":[{"name":"Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"He","sequence":"additional","affiliation":[{"name":"Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Xian","family":"Xu","sequence":"additional","affiliation":[{"name":"Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yu","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, 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