{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T16:38:33Z","timestamp":1789922313485,"version":"4.0.1"},"reference-count":59,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:00:00Z","timestamp":1617753600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Heart and Stroke Foundation Canadian Partnership for Stroke Recovery"},{"DOI":"10.13039\/100015099","name":"Canadian Vascular Network","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015099","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:p>Evidence supports early rehabilitation after stroke to limit disability. However, stroke survivors are typically sedentary and experience significant cardiovascular and muscular deconditioning. Despite growing consensus that preclinical and clinical stroke recovery research should be aligned, there have been few attempts to incorporate cardiovascular and skeletal muscle deconditioning into animal models of stroke. Here, we demonstrate in rats that a hindlimb sensorimotor cortex stroke results in both cardiovascular and skeletal muscle deconditioning and impairments in gait akin to those observed in humans. To reduce poststroke behavioral, cardiovascular, and skeletal muscle perturbations, we then used a combinatorial intervention consisting of aerobic and resistance exercise in conjunction with administration of resveratrol (RESV), a drug with exercise mimetic properties. A combination of aerobic and resistance exercise mitigated decreases in cardiovascular fitness and attenuated skeletal muscle abnormalities. RESV, beginning 24 hours poststroke, reduced acute hindlimb impairments, improved recovery in hindlimb function, increased vascular density in the perilesional cortex, and attenuated skeletal muscle fiber changes. Early RESV treatment and aerobic and resistance exercise independently provided poststroke benefits, at a time when individuals are rapidly becoming deconditioned as a result of inactivity. Although no additive effects were observed in these experiments, this approach represents a promising strategy to reduce poststroke behavioral impairments and minimize deconditioning. As such, this treatment regime has potential for enabling patients to engage in more intensive rehabilitation at an earlier time following stroke when mechanisms of neuroplasticity are most prevalent.<\/jats:p>","DOI":"10.1177\/15459683211005019","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T05:12:54Z","timestamp":1617772374000},"page":"471-485","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["An Exercise Mimetic Approach to Reduce Poststroke Deconditioning and Enhance Stroke Recovery"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0171-6102","authenticated-orcid":false,"given":"Matthew W.","family":"McDonald","sequence":"first","affiliation":[{"name":"University of Ottawa, ON, Canada"},{"name":"Canadian Partnership for Stroke Recovery, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4148-2638","authenticated-orcid":false,"given":"Matthew S.","family":"Jeffers","sequence":"additional","affiliation":[{"name":"University of Ottawa, ON, Canada"},{"name":"Canadian Partnership for Stroke Recovery, Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lama","family":"Issa","sequence":"additional","affiliation":[{"name":"University of Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Carter","sequence":"additional","affiliation":[{"name":"Canadian Partnership for Stroke Recovery, Ottawa, ON, Canada"},{"name":"Ottawa Hospital Research Institute, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allyson","family":"Ripley","sequence":"additional","affiliation":[{"name":"University of Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3029-8907","authenticated-orcid":false,"given":"Lydia M.","family":"Kuhl","sequence":"additional","affiliation":[{"name":"University of Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Morse","sequence":"additional","affiliation":[{"name":"University of Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar H.","family":"Comin","sequence":"additional","affiliation":[{"name":"Federal University of S\u00e3o Carlos, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard J.","family":"Jasmin","sequence":"additional","affiliation":[{"name":"University of Ottawa, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baptiste","family":"Lacoste","sequence":"additional","affiliation":[{"name":"University of Ottawa, ON, Canada"},{"name":"Canadian Partnership for Stroke Recovery, Ottawa, ON, Canada"},{"name":"Ottawa Hospital Research Institute, ON, Canada"},{"name":"University of Ottawa Brain and Mind Research Institute, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0217-4576","authenticated-orcid":false,"given":"Dale","family":"Corbett","sequence":"additional","affiliation":[{"name":"University of Ottawa, ON, Canada"},{"name":"Canadian Partnership for Stroke Recovery, Ottawa, ON, Canada"},{"name":"University of Ottawa Brain and Mind Research Institute, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,4,7]]},"reference":[{"key":"bibr1-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24653"},{"key":"bibr2-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3834-03.2004"},{"key":"bibr3-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1177\/1545968317753074"},{"key":"bibr4-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1177\/1545968311407517"},{"key":"bibr5-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2735"},{"key":"bibr6-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000120727.40792.40"},{"key":"bibr7-15459683211005019","first-page":"366","volume":"25","author":"Barrett M","year":"2018","journal-title":"Top Stroke Rehabil"},{"key":"bibr8-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1310\/GEEU-YRUY-VJ72-LEAR"},{"key":"bibr9-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-4949.2010.00467.x"},{"key":"bibr10-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-014-0519-8"},{"key":"bibr11-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000383"},{"key":"bibr12-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1177\/1545968317724285"},{"key":"bibr13-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1177\/1545968319886444"},{"key":"bibr14-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1519\/JPT.0b013e318236db92"},{"key":"bibr15-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(01)00434-3"},{"key":"bibr16-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1177\/1545968318765692"},{"key":"bibr17-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2014.06.007"},{"key":"bibr18-15459683211005019","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00343"},{"key":"bibr19-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.230490"},{"key":"bibr20-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.11.013"},{"key":"bibr21-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2008.04.007"},{"key":"bibr22-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1732163"},{"key":"bibr23-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.08.018"},{"key":"bibr24-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.04297.x"},{"key":"bibr25-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000022"},{"key":"bibr26-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8485624"},{"key":"bibr27-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1177\/1479164118815279"},{"key":"bibr28-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035273"},{"key":"bibr29-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.82"},{"key":"bibr30-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2012.02.001"},{"key":"bibr31-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2009.07.029"},{"key":"bibr32-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/410972"},{"key":"bibr33-15459683211005019","first-page":"25","volume":"32","author":"Von Schroeder HP","year":"1995","journal-title":"J Rehabil Res Dev"},{"key":"bibr34-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1179\/1476830515Y.0000000020"},{"key":"bibr35-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.04.044"},{"key":"bibr36-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.11.026"},{"key":"bibr37-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002048"},{"key":"bibr38-15459683211005019","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.01187"},{"key":"bibr39-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1179\/016164110X12670144526309"},{"key":"bibr40-15459683211005019","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14048570"},{"key":"bibr41-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60690-0"},{"key":"bibr42-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2015.1133027"},{"key":"bibr43-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-011-0561-8"},{"key":"bibr44-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1080\/02699050410001672305"},{"key":"bibr45-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e31825f18e1"},{"key":"bibr46-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-200409000-00001"},{"key":"bibr47-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1177\/1099800405283566"},{"key":"bibr48-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(96)00220-1"},{"key":"bibr49-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1682\/JRRD.2007.02.0040"},{"key":"bibr50-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20085"},{"key":"bibr51-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1080\/10749357.2017.1292720"},{"key":"bibr52-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000025"},{"key":"bibr53-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00455.2016"},{"key":"bibr54-15459683211005019","doi-asserted-by":"publisher","DOI":"10.3390\/molecules190914919"},{"key":"bibr55-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2013.08.012"},{"key":"bibr56-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-010-1545-0"},{"key":"bibr57-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1096\/fba.2020-00017"},{"key":"bibr58-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1161\/hc3701.096099"},{"key":"bibr59-15459683211005019","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.14.1682"}],"container-title":["Neurorehabilitation and Neural Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15459683211005019","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15459683211005019","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15459683211005019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:08:49Z","timestamp":1777705729000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15459683211005019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,7]]},"references-count":59,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1177\/15459683211005019"],"URL":"https:\/\/doi.org\/10.1177\/15459683211005019","relation":{},"ISSN":["1545-9683","1552-6844"],"issn-type":[{"value":"1545-9683","type":"print"},{"value":"1552-6844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,7]]}}}