{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:48:44Z","timestamp":1792882124729,"version":"4.5.0"},"reference-count":74,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013301","name":"Parkinson's Foundation","doi-asserted-by":"publisher","award":["PF-FBS-1898-18-01"],"award-info":[{"award-number":["PF-FBS-1898-18-01"]}],"id":[{"id":"10.13039\/100013301","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>Background. Gait impairments are common in Parkinson\u2019s disease (PD) and increase falls risk. Visual cues can improve gait in PD, particularly freezing of gait (FOG), but mechanisms involved in visual cue response are unknown. This study aimed to examine brain activity in response to visual cues in people with PD who do (PD+FOG) and do not report FOG (PD-FOG) and explore relationships between attention, brain activity and gait. Methods. Mobile EEG measured brain activity during gait in 20 healthy older adults and 43 PD participants (n=22 PD+FOG, n=21 PD-FOG). Participants walked for 2-minutes with and without visual cues (transverse lines to step over). We report power spectral density (PSD) in Delta (1-4\u00a0Hz), Theta (4-7\u00a0Hz), Alpha (8-12\u00a0Hz), Beta (14-24\u00a0Hz) and Gamma (30-50\u00a0Hz) bands within clusters of similarly brain localized independent component sources. Results. PSDs within the parietal and occipital lobes were altered when walking with visual cues in PD, particularly in PD+FOG. Between group, differences suggested that parietal sources in PD, particularly with PD+FOG, had larger activity compared to healthy older adults when walking. Within group, visual cues altered brain activity in PD, particularly in PD+FOG, within visual processing brain regions. In PD participants, brain activity differences with cues correlated with gait improvements, and in PD+FOG those with worse attention required more visual attentional processing (reduced alpha PSD) in the occipital lobe. Conclusions. Visual cues improve gait and influence brain activity during walking in PD, particularly in PD+FOG. Findings may allow development of more effective therapeutics.<\/jats:p>","DOI":"10.1177\/15459683211041317","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T07:20:57Z","timestamp":1631258457000},"page":"996-1009","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":48,"title":["Brain Activity Response to Visual Cues for Gait Impairment in Parkinson\u2019s Disease: An EEG Study"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6846-9372","authenticated-orcid":false,"given":"Samuel","family":"Stuart","sequence":"first","affiliation":[{"name":"Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne, UK"},{"name":"Northumbria Healthcare NHS foundation trust, North Tyneside, UK"},{"name":"Department of Neurology, Oregon Health and Science University, Portland, OR, 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