{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:01:21Z","timestamp":1777942881728,"version":"3.51.4"},"reference-count":48,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST-108-2321-B-038-002 and MOST 109-2321-B-038-002"],"award-info":[{"award-number":["MOST-108-2321-B-038-002 and MOST 109-2321-B-038-002"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>High-definition transcranial electrical theta burst superimposing direct current stimulation (HD-tDCS-eTBS) not only incorporates the therapeutic advantages of tDCS and TBS but enhances stimulation focality and practicality. However, the applicability of this innovative neuromodulatory device in post-stroke rehabilitation remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study aimed to assess the efficacy and safety of the HD-tDCS-eTBS on upper extremity (UE) motor function in patients with chronic stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A patient-blinded, randomized controlled study was conducted. Twenty-four participants were randomly assigned into either the active HD-tDCS-eTBS group or sham HD-tDCS-eTBS group. Both groups received 20\u2009minutes of active\/sham HD-tDCS-eTBS combined with 30\u2009minutes of conventional UE rehabilitation each time, 3 times a week for 4\u2009weeks. Outcome measures including the Fugl-Meyer Assessment of Upper Extremity, Wolf Motor Function Test, Jebsen-Taylor Hand Function Test, Finger-Nose Test, and Modified Ashworth Scale were assessed before and immediately after the intervention period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Spasticity of shoulder adductor ( P\u2009=\u2009.05), elbow extensor ( P\u2009=\u2009.04), and thumb flexor ( P\u2009&lt;\u2009.01) were significantly reduced in the active HD-tDCS-eTBS group versus the sham group. Nonsignificant trends in the improvements of most other outcome measures were in favor of the active HD-tDCS-eTBS group with moderate to large effect sizes ( P\u2009=\u2009.06\u2013.26, \u03b7\n                      <jats:sub>p<\/jats:sub>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.06\u20130.16). No severe adverse events except for slight skin redness under the stimulus electrode was detected after the HD-tDCS-eTBS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our findings support that HD-tDCS-eTBS is safe and has therapeutic potential for post-stroke UE motor rehabilitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>ClinicalTrials.gov (ID: NCT04278105).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15459683221121751","type":"journal-article","created":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T07:34:44Z","timestamp":1662017684000},"page":"645-654","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["High-Definition Transcranial Direct Current with Electrical Theta Burst on Post-Stroke Motor Rehabilitation: A Pilot Randomized Controlled Trial"],"prefix":"10.1177","volume":"36","author":[{"given":"Yi-Jing","family":"Huang","sequence":"first","affiliation":[{"name":"School of Occupational Therapy, College of Medicine, National Taiwan University, Taipei"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun-Min","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering, National Cheng Kung University, Tainan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chieh","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chien-An","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering, National Cheng Kung University, Tainan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-Jin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, College of Engineering, National Cheng Kung University, Tainan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih-Wei","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei"},{"name":"International PhD Program in Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei"},{"name":"School of Gerontology and Long-Term Care, College of Nursing, Taipei Medical 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