{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:57:23Z","timestamp":1793066243279,"version":"4.5.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100008244","name":"Direkt\u00f8r Jacob Madsen og Hustru Olga Madsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008244","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","award":["123878"],"award-info":[{"award-number":["123878"]}],"id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008361","name":"Scleroseforeningen","doi-asserted-by":"publisher","award":["A33634"],"award-info":[{"award-number":["A33634"]}],"id":[{"id":"10.13039\/100008361","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008361","name":"Scleroseforeningen","doi-asserted-by":"publisher","award":["A35468"],"award-info":[{"award-number":["A35468"]}],"id":[{"id":"10.13039\/100008361","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004954","name":"Augustinus Fonden","doi-asserted-by":"publisher","award":["17-2194"],"award-info":[{"award-number":["17-2194"]}],"id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021817","name":"Knud og Edith Eriksens Mindefond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021817","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Exercise positively affects multiple sclerosis (MS) symptoms, physiological systems, and potentially cognition. However, an uninvestigated \u201cwindow of opportunity\u201d exists for exercise therapy early in the disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study presents secondary analyses from the Early Multiple Sclerosis Exercise Study, and aims to investigate the efficacy of exercise on physical function, cognition, and patient-reported measures of disease and fatigue impact early in the disease course of MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomized controlled trial (n\u2009=\u200984, time since diagnosis &lt;2\u2009years) included 48\u2009weeks of aerobic exercise or an active control condition (health education) and between-group changes are based on repeated measurement mixed regression models. Physical function tests included measures of aerobic fitness, walking (6-minute walk, Timed 25-foot walk, Six-spot step test), and upper-limb dexterity. Tests of processing speed and memory evaluated cognition. The questionnaires Multiple Sclerosis Impact Scale and Modified Fatigue Impact Scale assessed perception of disease and fatigue impact.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following early exercise aerobic fitness showed superior between-group physiological adaptations (4.0 [1.7; 6.3]\u2009ml O\n                      <jats:sub>2<\/jats:sub>\n                      \/min\/kg; large effect size [ES\u2009=\u20090.90]). No other outcomes showed significant between-group differences, yet all measures of walking and upper-limb function showed small-to-medium effect sizes in favor of exercise (ES\u2009=\u20090.19\u22120.58). Overall disability status as well as cognition were unaffected by exercise, whereas perception of disease and fatigue impact were reduced in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In early MS, 48\u2009weeks of supervised aerobic exercise seem to positively modify physical function, but not cognitive function. Perception of disease and fatigue impact may be modifiable by exercise in early MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration:<\/jats:title>\n                    <jats:p>Clinicaltrials.gov (identifier: NCT03322761).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15459683231159659","type":"journal-article","created":{"date-parts":[[2023,3,11]],"date-time":"2023-03-11T01:39:38Z","timestamp":1678498778000},"page":"288-297","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":15,"title":["Exercise Therapy in Early Multiple Sclerosis Improves Physical Function But Not Cognition: Secondary Analyses From a Randomized Controlled Trial"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1903-0333","authenticated-orcid":false,"given":"Morten","family":"Riemenschneider","sequence":"first","affiliation":[{"name":"Exercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3233-0429","authenticated-orcid":false,"given":"Lars G.","family":"Hvid","sequence":"additional","affiliation":[{"name":"Exercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark"},{"name":"The Danish MS Hospitals, Ry and Haslev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor","family":"Petersen","sequence":"additional","affiliation":[{"name":"The Multiple Sclerosis Clinic, Department of Neurology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egon","family":"Stenager","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research, University of Southern Denmark, Odense, Denmark"},{"name":"MS-Clinic of Southern Jutland (S\u00f8nderborg, Esbjerg, Kolding), Department of Neurology, S\u00f8nderborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4132-2789","authenticated-orcid":false,"given":"Ulrik","family":"Dalgas","sequence":"additional","affiliation":[{"name":"Exercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"bibr1-15459683231159659","doi-asserted-by":"publisher","DOI":"10.1177\/1352458517751646"},{"key":"bibr2-15459683231159659","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2017.08.003"},{"key":"bibr3-15459683231159659","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2016.07.003"},{"key":"bibr4-15459683231159659","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001462"},{"key":"bibr5-15459683231159659","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12235"},{"key":"bibr6-15459683231159659","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13692"},{"key":"bibr7-15459683231159659","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520936231"},{"key":"bibr8-15459683231159659","doi-asserted-by":"publisher","DOI":"10.1016\/j.rehab.2021.101491"},{"key":"bibr9-15459683231159659","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-019-1002-3"},{"key":"bibr10-15459683231159659","doi-asserted-by":"publisher","DOI":"10.1177\/1352458518777377"},{"key":"bibr11-15459683231159659","doi-asserted-by":"publisher","DOI":"10.1177\/13524585221079200"},{"key":"bibr12-15459683231159659","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-043699"},{"key":"bibr13-15459683231159659","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-955113"},{"key":"bibr14-15459683231159659","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-130975"},{"key":"bibr15-15459683231159659","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2377-14-58"},{"key":"bibr16-15459683231159659","volume-title":"Multiple Sclerosis Functional Composite (MSFC); 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