{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:09:08Z","timestamp":1789578548641,"version":"build-2803163510"},"reference-count":53,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background.<\/jats:title>\n                    <jats:p>Altered dynamic functional connectivity has been associated with motor impairments in the acute phase post-stroke. Its association with somatosensory impairments in the early sub-acute phase remains unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective.<\/jats:title>\n                    <jats:p>To investigate altered dynamic functional connectivity associated with somatosensory impairments in the early sub-acute phase post-stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods.<\/jats:title>\n                    <jats:p>\n                      We collected resting state magnetic resonance imaging and clinical somatosensory function of the upper limb of 20 subacute stroke patients and 16 healthy controls (HC). A sliding-window approach was used to identify 3 connectivity states based on the estimated dynamic functional connectivity of sensorimotor related networks. Network components were subdivided into 3 domains: cortical and subcortical sensorimotor, as well as cognitive control network. Between-group differences were investigated using independent\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -tests and Mann\u2013Whitney-\n                      <jats:italic toggle=\"yes\">U<\/jats:italic>\n                      tests. Analyzes were performed with correction for age, head motion and time post-stroke and corrected for multiple comparisons.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results.<\/jats:title>\n                    <jats:p>\n                      Stroke patients spent significantly less time in a weakly connected network state (state 3; dwell time:\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      <jats:sub>state3<\/jats:sub>\n                      \u2009=\u20090.003, mean\n                      <jats:sub>stroke<\/jats:sub>\n                      \u2009=\u200953.02, SD\n                      <jats:sub>stroke<\/jats:sub>\n                      \u2009=\u200953.13; mean\n                      <jats:sub>HC<\/jats:sub>\n                      \u2009=\u2009118.92, SD\n                      <jats:sub>HC<\/jats:sub>\n                      \u2009=\u200972.84), and stayed shorter but more time intervals in a highly connected intra-domain network state (state 1; fraction time:\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      <jats:sub>state 1<\/jats:sub>\n                      \u2009&lt;\u20090.001, mean\n                      <jats:sub>stroke<\/jats:sub>\n                      \u2009=\u20090.46, SD\n                      <jats:sub>stroke<\/jats:sub>\n                      \u2009=\u20090.26; mean\n                      <jats:sub>HC<\/jats:sub>\n                      \u2009=\u20090.26, SD\n                      <jats:sub>HC<\/jats:sub>\n                      \u2009=\u20090.21) compared to HC. After 8\u2009weeks of therapy, improvements in wrist proprioception were moderately associated with decreases in dwell and fraction times toward a more normalized pattern.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion.<\/jats:title>\n                    <jats:p>Changes in temporal properties of large-scale network interactions are present in the early rehabilitation phase post-stroke and could indicate enhanced neural plasticity. These findings could augment the understanding of cerebral reorganization after loss of neural tissue specialized in somatosensory functions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15459683231179172","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T14:37:08Z","timestamp":1687617428000},"page":"423-433","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Altered Dynamic Resting State Functional Connectivity Associated With Somatosensory Impairments in the Upper Limb in the Early Sub-Acute Phase Post-Stroke"],"prefix":"10.1177","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8011-1303","authenticated-orcid":false,"given":"Nele De","family":"Bruyn","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Sciences, KU Leuven-University of Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna K.","family":"Bonkhoff","sequence":"additional","affiliation":[{"name":"J. 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