{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:23:39Z","timestamp":1790112219666,"version":"4.0.1"},"reference-count":65,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"BeAble Health Pvt Ltd"},{"name":"Society of Indian Physiotherapists","award":["SIP_2021_YR01"],"award-info":[{"award-number":["SIP_2021_YR01"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background1<\/jats:title>\n                    <jats:p>Despite a growing interest in gaming rehabilitation for upper limb (UL) recovery post-stroke, studies investigating the effects of game-based rehabilitation incorporating functional games are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the efficacy of an intensive, functional, gamified rehabilitation program compared to task-based training on UL motor function in acute\/sub-acute stroke survivors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This randomized, multicenter, single-blind, clinical trial comprises 120 participants with unilateral stroke who were randomized to receive either gamified training (n\u2009=\u200964) using the ArmAble\u2122 [experimental group (EG)] or task-based training (n\u2009=\u200956) in conjunction with conventional therapy for 2\u2009hours per day, 6\u2009days per week for 2\u2009weeks, followed by UL rehabilitation for another 4\u2009weeks at home. Primary outcomes evaluated by a blinded assessor included the Fugl-Meyer Assessment-Upper Extremity (FM-UE), and Action Research Arm Test (ARAT). Data were analyzed using a linear mixed-effect regression model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean (standard deviation) age of the participants was 54.4\u2009\u00b1\u200911.7\u2009years (78.1% men) in the EG and 57.7\u2009\u00b1\u200910.9\u2009years (73.2% men) in the comparator group (CG). The median (interquartile range) time since stroke was 30.0 (54.0) days in the EG and 22.5 (45.0) days in the CG. Following the 2-week intervention, a statistically significant improvement was observed in the EG for the FM-UE [between-group mean differences (95% confidence interval): \u22123.9 (\u22126.5, \u22121.3); P\u2009=\u2009.003]; but not for the ARAT [\u22122.9 (\u22125.8, 0.0); P\u2009=\u2009.051]. Gains at 6\u2009weeks were significantly greater in the EG for both FM-UE [\u22123.9 (\u22126.5, \u22121.3); P\u2009=\u2009.003]; and ARAT [\u22123.0 (\u22125.9, \u22120.0); P\u2009=\u2009.046].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Gamified rehabilitation using the ArmAble\u2122 device has shown immediate and short-term improvement in UL function after acute\/sub-acute stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trials Registry Number:<\/jats:title>\n                    <jats:p>CTRI\/2020\/09\/027651<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15459683231222921","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T08:07:56Z","timestamp":1706515676000},"page":"243-256","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["Effectiveness of an Intensive, Functional, and Gamified Rehabilitation Program on Upper Limb Function in People With Stroke (EnteRtain): A Multicenter Randomized Clinical Trial"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5000-7284","authenticated-orcid":false,"given":"A. Sulfikar","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6491-2584","authenticated-orcid":false,"given":"D. Senthil","family":"Kumaran","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amritha","family":"Unni","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjukta","family":"Sardesai","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasudeva","family":"Prabhu","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, SDM Ayurveda Hospital, Udupi, Karnataka, 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