{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:40:07Z","timestamp":1780072807248,"version":"3.54.0"},"reference-count":62,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100011277","name":"State Key Laboratory of Trauma, Burn and Combined Injury","doi-asserted-by":"crossref","award":["SKLYQ202002"],"award-info":[{"award-number":["SKLYQ202002"]}],"id":[{"id":"10.13039\/501100011277","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371333"],"award-info":[{"award-number":["82371333"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371399"],"award-info":[{"award-number":["82371399"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chongqing Medical Scientific Research Project","award":["2023GGXM003"],"award-info":[{"award-number":["2023GGXM003"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anodal transcranial direct current stimulation (AtDCS), a neuromodulatory technique, has been applied to treat traumatic brain injury (TBI) in patients and was reported to promote functional improvement. We evaluated the effect of contralesional AtDCS on axonal sprouting of the intact corticospinal tract (CST) and the underlying mechanism in a TBI mouse model to provide more preclinical evidence for the use of AtDCS to treat TBI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>TBI was induced in mice by a contusion device. Then, the mice were subjected to contralesional AtDCS 5\u2009days per week followed by a 2-day interval for 7\u2009weeks. After AtDCS, motor function was evaluated by the irregular ladder walking, narrow beam walking, and open field tests. CST sprouting was assessed by anterograde and retrograde labeling of corticospinal neurons (CSNs), and the effect of AtDCS was further validated by pharmacogenetic inhibition of axonal sprouting using clozapine-N-oxide (CNO).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>TBI resulted in damage to the ipsilesional cortex, while the contralesional CST remained intact. AtDCS improved the skilled motor functions of the impaired hindlimb in TBI mice by promoting CST axon sprouting, specifically from the intact hemicord to the denervated hemicord. Furthermore, electrical stimulation of CSNs significantly increased the excitability of neurons and thus activated the mechanistic target of rapamycin (mTOR) pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Contralesional AtDCS improved skilled motor following TBI, partly by promoting axonal sprouting through increased neuronal activity and thus activation of the mTOR pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15459683241233261","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T05:56:21Z","timestamp":1708581381000},"page":"214-228","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Contralesional Anodal Transcranial Direct Current Stimulation Promotes Intact Corticospinal Tract Axonal Sprouting and Functional Recovery After Traumatic Brain Injury in Mice"],"prefix":"10.1177","volume":"38","author":[{"given":"Beike","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery and State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"},{"name":"Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"},{"name":"Chongqing Key Laboratory of Precision Neuromedicine and Neuroregenaration, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Tan","sequence":"additional","affiliation":[{"name":"Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"},{"name":"Chongqing Key Laboratory of Precision Neuromedicine and Neuroregenaration, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"},{"name":"Department of Blood Transfusion, The General Hospital of Western Theater Command, Chengdu, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"},{"name":"Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"},{"name":"Chongqing Key Laboratory of Precision Neuromedicine and Neuroregenaration, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"},{"name":"Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"},{"name":"Chongqing Key Laboratory of Precision Neuromedicine and Neuroregenaration, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhong","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Neurobiology, College of Basic Medical Science, Third Military Medical University (Army Medical University), Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelong","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Bioengineering, Chongqing University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"},{"name":"Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"},{"name":"Department of Neurosurgery, The 904th Hospital of PLA, School of Medicine of Anhui Medical University, Wuxi, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weina","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"},{"name":"Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"},{"name":"Chongqing Key Laboratory of Precision Neuromedicine and Neuroregenaration, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"},{"name":"Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"},{"name":"Chongqing Key Laboratory of Precision Neuromedicine and Neuroregenaration, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9905-9138","authenticated-orcid":false,"given":"Yujie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"},{"name":"Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"},{"name":"Chongqing Key Laboratory of Precision Neuromedicine and Neuroregenaration, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"},{"name":"Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"},{"name":"Chongqing Key Laboratory of Precision Neuromedicine and Neuroregenaration, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,22]]},"reference":[{"key":"bibr1-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00309-X"},{"key":"bibr2-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1016\/j.injury.2014.10.064"},{"key":"bibr3-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181e7ca58"},{"key":"bibr4-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1682\/jrrd.2006.12.0158"},{"key":"bibr5-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00065-0"},{"key":"bibr6-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.0089"},{"key":"bibr7-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pbr.2014.12.010"},{"key":"bibr8-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn5899"},{"key":"bibr9-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6451-11.2012"},{"key":"bibr10-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3489-07.2007"},{"key":"bibr11-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2018.05.004"},{"key":"bibr12-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01104.2010"},{"key":"bibr13-15459683241233261","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2018.00080"},{"key":"bibr14-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-022-00959-x"},{"key":"bibr15-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2022.102332"},{"key":"bibr16-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2022.0286"},{"key":"bibr17-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1177\/1073858410386614"},{"key":"bibr18-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz252"},{"key":"bibr19-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.6331"},{"key":"bibr20-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1186\/s12984-019-0489-9"},{"key":"bibr21-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2014.162"},{"key":"bibr22-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-11-59"},{"key":"bibr23-15459683241233261","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00134"},{"key":"bibr24-15459683241233261","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.337053"},{"key":"bibr25-15459683241233261","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.857415"},{"key":"bibr26-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14184"},{"key":"bibr27-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.007626"},{"key":"bibr28-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.07.037"},{"key":"bibr29-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X19882788"},{"key":"bibr30-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1016\/s0301-0082(96)00021-4"},{"key":"bibr31-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2603"},{"key":"bibr32-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.02.017"},{"key":"bibr33-15459683241233261","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2015.00075"},{"key":"bibr34-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.2c00304"},{"key":"bibr35-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30469-1"},{"key":"bibr36-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30499-X"},{"key":"bibr37-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2021.0062"},{"key":"bibr38-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30371-X"},{"key":"bibr39-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0280-3"},{"key":"bibr40-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa321"},{"key":"bibr41-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9898439"},{"key":"bibr42-15459683241233261","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00835"},{"key":"bibr43-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2018.5769"},{"key":"bibr44-15459683241233261","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12050540"},{"key":"bibr45-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1177\/0963689719834870"},{"key":"bibr46-15459683241233261","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.935781"},{"key":"bibr47-15459683241233261","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2023.1147693"},{"key":"bibr48-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2015.12.008"},{"key":"bibr49-15459683241233261","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.327324"},{"key":"bibr50-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3002044"},{"key":"bibr51-15459683241233261","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.355762"},{"key":"bibr52-15459683241233261","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00558"},{"key":"bibr53-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.10.029"},{"key":"bibr54-15459683241233261","volume-title":"Neuroplasticity","author":"Puderbaugh M","year":"2023"},{"key":"bibr55-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2011.07.008"},{"key":"bibr56-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-017-0588-5"},{"key":"bibr57-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.11.014"},{"key":"bibr58-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30415-0"},{"key":"bibr59-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1186\/s12984-023-01297-3"},{"key":"bibr60-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1177\/15459683231209722"},{"key":"bibr61-15459683241233261","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2012.00088"},{"key":"bibr62-15459683241233261","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.649756"}],"container-title":["Neurorehabilitation and Neural Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15459683241233261","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15459683241233261","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15459683241233261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:10:23Z","timestamp":1777705823000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15459683241233261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,22]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1177\/15459683241233261"],"URL":"https:\/\/doi.org\/10.1177\/15459683241233261","relation":{},"ISSN":["1545-9683","1552-6844"],"issn-type":[{"value":"1545-9683","type":"print"},{"value":"1552-6844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,22]]}}}