{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:01:49Z","timestamp":1777942909164,"version":"3.51.4"},"reference-count":63,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K01HD092556"],"award-info":[{"award-number":["K01HD092556"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The potential for aerobic exercise (AE) to enhance neuroplasticity post-stroke has been theorized but not systematically investigated. Our aim was to determine the effects of forced-rate AE (FE) paired with upper extremity (UE) repetitive task practice (FE + RTP) compared to time-matched UE RTP (RTP only) on motor recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A single center randomized clinical trial was conducted from April 2019 to December 2022. Sixty individuals \u22656 months post-stroke with UE hemiparesis were randomized to FE + RTP (N = 30) or RTP only (N = 30), completing 90-minute sessions, 3\u00d7\/week for 8 weeks. The FE + RTP group underwent 45-minute of FE (5-minute warm-up, 35-minute main set, and 5-minute cool down) followed by 45-minute of UE RTP. The RTP only group completed 90-minute of RTP. Primary outcomes were the Fugl-Meyer Assessment (FMA) and Action Research Arm Test (ARAT). The 6-minute Walk Test (6MWT, secondary outcome) assessed walking capacity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sixty individuals enrolled and 56 completed the study. The RTP only group completed more RTP in terms of repetitions (411.8 \u00b1 44.4 vs 222.8 \u00b1 28.4, P &lt; .001) and time (72.7 \u00b1 6.7 vs 37.8 \u00b1 2.4 minutes, P &lt; .001) versus FE + RTP. There was no significant difference between groups on the FMA (FE + RTP, 36.2 \u00b1 10.1-44.0 \u00b1 11.8 and RTP only, 34.4 \u00b1 11.0-41.2 \u00b1 13.4, P = .43) or ARAT (FE + RTP, 32.5 \u00b1 16.6-37.7 \u00b1 17.9 and RTP only, 32.8 \u00b1 18.6-36.4 \u00b1 18.5, P = .88). The FE + RTP group demonstrated greater improvements on the 6MWT (274.9 \u00b1 122.0-327.1 \u00b1 141.2 m) versus RTP only (285.5 \u00b1 160.3-316.9 \u00b1 170.0, P = .003).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There was no significant difference between groups in the primary outcomes. The FE + RTP improved more on the 6MWT, a secondary outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration:<\/jats:title>\n                    <jats:p>ClinicalTrials.gov : NCT03819764.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15459683241233577","type":"journal-article","created":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T05:21:21Z","timestamp":1709184081000},"page":"291-302","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["The Utilization of Forced-Rate Cycling to Facilitate Motor Recovery Following Stroke: A Randomized Clinical Trial"],"prefix":"10.1177","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9094-9740","authenticated-orcid":false,"given":"Susan M.","family":"Linder","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Cleveland 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