{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:05:11Z","timestamp":1793361911050,"version":"4.5.0"},"reference-count":56,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K99MH126161"],"award-info":[{"award-number":["K99MH126161"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00HD091375"],"award-info":[{"award-number":["R00HD091375"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The application of neuroimaging-based biomarkers in stroke has enriched our understanding of post-stroke recovery mechanisms, including alterations in functional connectivity based on synchronous oscillatory activity across various cortical regions. Phase-amplitude coupling, a type of cross-frequency coupling, may provide additional mechanistic insight.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine how the phase of prefrontal cortex delta (1-3\u2009Hz) oscillatory activity mediates the amplitude of motor cortex beta (13-20\u2009Hz) oscillations in individual\u2019s early post-stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants admitted to an inpatient rehabilitation facility completed resting and task-based EEG recordings and motor assessments around the time of admission and discharge along with structural neuroimaging. Unimpaired controls completed EEG procedures during a single visit. Mixed-effects linear models were performed to assess within- and between-group differences in delta-beta prefrontomotor coupling. Associations between coupling and motor status and injury were also determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty individuals with stroke and 17 unimpaired controls participated. Coupling was greater during task versus rest conditions for all participants. Though coupling during affected extremity task performance decreased during hospitalization, coupling remained elevated at discharge compared to controls. Greater baseline coupling was associated with better motor status at admission and discharge and positively related to motor recovery. Coupling demonstrated both positive and negative associations with injury involving measures of lesion volume and overlap injury to anterior thalamic radiation, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This work highlights the utility of prefrontomotor cross-frequency coupling as a potential motor status and recovery biomarker in stroke. The frequency- and region-specific neurocircuitry featured in this work may also facilitate novel treatment strategies in stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15459683241257523","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T06:16:52Z","timestamp":1717654612000},"page":"506-517","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Cross-Frequency Coupling as a Biomarker for Early Stroke Recovery"],"prefix":"10.1177","volume":"38","author":[{"given":"Jasper I.","family":"Mark","sequence":"first","affiliation":[{"name":"Human Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"},{"name":"Department of Health Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Riddle","sequence":"additional","affiliation":[{"name":"Department of Psychology, Florida State University, Tallahassee, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachana","family":"Gangwani","sequence":"additional","affiliation":[{"name":"Human Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"},{"name":"Department of Health Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavio","family":"Fr\u00f6hlich","sequence":"additional","affiliation":[{"name":"Carolina Center for Neurostimulation, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"},{"name":"Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3469-0399","authenticated-orcid":false,"given":"Jessica M.","family":"Cassidy","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"issue":"3","key":"bibr1-15459683241257523","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/ana.21393","volume":"63","author":"Cramer SC. Repairing the human brain after stroke: I","year":"2008","journal-title":"Ann Neurol"},{"key":"bibr2-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.018844"},{"key":"bibr3-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2018.08.009"},{"key":"bibr4-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-91978-7"},{"key":"bibr5-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25643"},{"key":"bibr6-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv156"},{"key":"bibr7-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy195"},{"key":"bibr8-15459683241257523","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00194"},{"key":"bibr9-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1126\/science.1128115"},{"key":"bibr10-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2021.102033"},{"key":"bibr11-15459683241257523","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.21792"},{"key":"bibr12-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac136"},{"issue":"10","key":"bibr13-15459683241257523","first-page":"2079","volume":"32","author":"Riddle J","year":"2022","journal-title":"Cereb Cortex"},{"key":"bibr14-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2008.21020"},{"key":"bibr15-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1522551113"},{"issue":"2","key":"bibr16-15459683241257523","first-page":"239","volume":"13","author":"Quinlin EB","year":"2013","journal-title":"Curr Neurol Neurosci Rep"},{"key":"bibr17-15459683241257523","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2011.00008"},{"key":"bibr18-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2009.11.063"},{"key":"bibr19-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2012658118"},{"key":"bibr20-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.028932"},{"key":"bibr21-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00978.2015"},{"key":"bibr22-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1142\/p151"},{"key":"bibr23-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(02)00308-2"},{"key":"bibr24-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.10.046"},{"key":"bibr25-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19981221)402:3<327::AID-CNE4>3.0.CO;2-Z"},{"key":"bibr26-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/6.2.102"},{"key":"bibr27-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3386-05.2006"},{"key":"bibr28-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000001117"},{"key":"bibr29-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109090"},{"key":"bibr30-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhi089"},{"key":"bibr31-15459683241257523","volume-title":"Neuroanatomy, Thalamocortical Radiations","author":"George K","year":"2023"},{"key":"bibr32-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.06.024"},{"key":"bibr33-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40044-z"},{"key":"bibr34-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.025898"},{"key":"bibr35-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0283975"},{"key":"bibr36-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.11.004"},{"key":"bibr37-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2007.19.12.2082"},{"key":"bibr38-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00068.2021"},{"key":"bibr39-15459683241257523","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00573"},{"key":"bibr40-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24309"},{"key":"bibr41-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116189"},{"key":"bibr42-15459683241257523","volume-title":"MRI Atlas of Human White Matter","author":"Oishi K","year":"2010"},{"key":"bibr43-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab469"},{"key":"bibr44-15459683241257523","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.823202"},{"key":"bibr45-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2002.35473"},{"key":"bibr46-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.003168"},{"key":"bibr47-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.023"},{"key":"bibr48-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(99)00141-8"},{"key":"bibr49-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.02.001"},{"key":"bibr50-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27524"},{"key":"bibr51-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.10.002"},{"key":"bibr52-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.01.023"},{"key":"bibr53-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1177\/1545968320921824"},{"key":"bibr54-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-007-0029-0"},{"key":"bibr55-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-016-0467-5"},{"key":"bibr56-15459683241257523","doi-asserted-by":"publisher","DOI":"10.1177\/15459683231209136"}],"container-title":["Neurorehabilitation and Neural Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15459683241257523","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15459683241257523","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15459683241257523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:10:30Z","timestamp":1777705830000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15459683241257523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,6]]},"references-count":56,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["10.1177\/15459683241257523"],"URL":"https:\/\/doi.org\/10.1177\/15459683241257523","relation":{},"ISSN":["1545-9683","1552-6844"],"issn-type":[{"value":"1545-9683","type":"print"},{"value":"1552-6844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,6]]}}}