{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:17:07Z","timestamp":1790612227380,"version":"4.1.0"},"reference-count":58,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI-EX110-10913PI"],"award-info":[{"award-number":["NHRI-EX110-10913PI"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST-106-2314-B-010- 037-MY3"],"award-info":[{"award-number":["MOST-106-2314-B-010- 037-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gait disturbances are exacerbated in people with Parkinson\u2019s disease (PD) during dual-task walking (DTW). Transcranial direct current stimulation (tDCS) has been shown to exert beneficial effects on gait performance and cortical excitability in PD; however, its combined effects with treadmill training (TT) remain undetermined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the effects of tDCS followed by TT on DTW performance and cortical excitability in individuals with PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thirty-four PD participants were randomized to dorsal lateral prefrontal cortex (DLPFC) tDCS and TT group (DLPFC tDCS\u2009+\u2009TT group) or sham tDCS and TT group (sham tDCS\u2009+\u2009TT group) for 50\u2009minutes per session (20\u2009minutes tDCS followed by 30\u2009minutes TT), 12 sessions within 5\u2009weeks (2-3 sessions each week). Outcome measures included cognitive dual-task walking (CDTW), motor dual-task walking (MDTW), usual walking performance, cortical excitability, functional mobility, cognitive function, and quality of life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The DLPFC tDCS\u2009+\u2009TT group exerted significantly greater improvement in CDTW velocity ( P\u2009=\u2009.046), cadence ( P\u2009=\u2009.043), and stride time ( P\u2009=\u2009.041) compared to sham tDCS\u2009+\u2009TT group. In addition, DLPFC tDCS\u2009+\u2009TT group demonstrated a significant increase in resting motor threshold of stimulated hemisphere compared with sham tDCS\u2009+\u2009TT group ( P\u2009=\u2009.026). However, no significant differences between groups were found in MDTW performance and other outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Twelve-session DLPFC tDCS followed by TT significantly improved CDTW performance and decreased cortical excitability more than TT alone in individuals with PD. Applying DLPFC tDCS prior to TT could be suggested for gait rehabilitation in individuals with PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration number:<\/jats:title>\n                    <jats:p>Australian New Zealand Clinical Trials Registry ACTRN12622000101785<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15459683241268583","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T02:45:48Z","timestamp":1722912348000},"page":"680-692","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Effects of DLPFC tDCS Followed by Treadmill Training on Dual-Task Gait and Cortical Excitability in Parkinson\u2019s Disease: A Randomized Controlled Trial"],"prefix":"10.1177","volume":"38","author":[{"given":"Pei-Ling","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Physical Therapy and Assistive Technology, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1548-3511","authenticated-orcid":false,"given":"Yea-Ru","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Assistive Technology, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Fong","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Nerve Repair, Department of Neurosurgery, Taipei Veterans General Hospital, Taipei, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8738-796X","authenticated-orcid":false,"given":"Ray-Yau","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Assistive Technology, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,5]]},"reference":[{"key":"bibr1-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.116.2.220"},{"key":"bibr2-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.12.012"},{"key":"bibr3-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2004.01.025"},{"key":"bibr4-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1007\/s00221-011-2551-0"},{"key":"bibr5-15459683241268583","first-page":"918719","volume":"2012","author":"Kelly VE","year":"2012","journal-title":"Parkinsons Dis"},{"key":"bibr6-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(01)00158-8"},{"key":"bibr7-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(02)00301-2"},{"key":"bibr8-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2015.02.001"},{"key":"bibr9-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa274"},{"key":"bibr10-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23378"},{"key":"bibr11-15459683241268583","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2020.00190"},{"key":"bibr12-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29595"},{"issue":"3","key":"bibr13-15459683241268583","first-page":"131","volume":"27","author":"Badawy RA","year":"2012","journal-title":"Funct Neurol"},{"issue":"6","key":"bibr14-15459683241268583","first-page":"1586","volume":"27","author":"Jones DT","year":"2021","journal-title":"Continuum (Minneap Minn)"},{"key":"bibr15-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/62.9.1048"},{"key":"bibr16-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1186\/s40814-016-0099-2"},{"key":"bibr17-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1177\/1545968320924430"},{"key":"bibr18-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1097\/NPT.0000000000000402"},{"key":"bibr19-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2009.04.001"},{"key":"bibr20-15459683241268583","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-210190"},{"key":"bibr21-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-021-00245-2"},{"key":"bibr22-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.11.019"},{"key":"bibr23-15459683241268583","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.843122"},{"key":"bibr24-15459683241268583","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.807151"},{"key":"bibr25-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2018.12.001"},{"key":"bibr26-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2014.03.043"},{"key":"bibr27-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1177\/0269215514534277"},{"key":"bibr28-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007830.pub3"},{"key":"bibr29-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(03)00235-9"},{"key":"bibr30-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0000000000000397"},{"key":"bibr31-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2022.04.029"},{"key":"bibr32-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1249\/00005768-198205000-00012"},{"key":"bibr33-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218180"},{"key":"bibr34-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.11.004"},{"key":"bibr35-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1177\/1545968312451915"},{"issue":"1","key":"bibr36-15459683241268583","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1093\/brain\/awh315","volume":"128","author":"Murase N","year":"2005","journal-title":"Brain"},{"key":"bibr37-15459683241268583","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00126"},{"key":"bibr38-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/81.2.810"},{"key":"bibr39-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijge.2018.06.003"},{"key":"bibr40-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1007\/BF02260863"},{"key":"bibr41-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1002\/hec.4510"},{"key":"bibr42-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0258(20000715)19:13<1793::AID-SIM482>3.0.CO;2-Q"},{"key":"bibr43-15459683241268583","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.766649"},{"key":"bibr44-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2020.11.012"},{"key":"bibr45-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0287252"},{"key":"bibr46-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaitpost.2018.03.041"},{"key":"bibr47-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1097\/NPT.0000000000000055"},{"key":"bibr48-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-022-02514-4"},{"key":"bibr49-15459683241268583","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.746797"},{"key":"bibr50-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.09.032"},{"key":"bibr51-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2023.02.010"},{"key":"bibr52-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhy093"},{"key":"bibr53-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0443-4"},{"issue":"01","key":"bibr54-15459683241268583","volume":"25","author":"Petzinger GM","year":"2010","journal-title":"Mov Disord"},{"issue":"1","key":"bibr55-15459683241268583","first-page":"55","volume":"49","author":"Karim AA","year":"2004","journal-title":"Biomedizinische Technik"},{"key":"bibr56-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1162\/jocn.2006.18.9.1577"},{"key":"bibr57-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1177\/15459683211019344"},{"key":"bibr58-15459683241268583","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2015.07.043"}],"container-title":["Neurorehabilitation and Neural Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15459683241268583","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15459683241268583","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15459683241268583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:10:34Z","timestamp":1777705834000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15459683241268583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,5]]},"references-count":58,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1177\/15459683241268583"],"URL":"https:\/\/doi.org\/10.1177\/15459683241268583","relation":{},"ISSN":["1545-9683","1552-6844"],"issn-type":[{"value":"1545-9683","type":"print"},{"value":"1552-6844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,5]]}}}