{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:06:05Z","timestamp":1792191965417,"version":"4.4.0"},"reference-count":51,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2024,8,14]],"date-time":"2024-08-14T00:00:00Z","timestamp":1723593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["PSI2014-55087-R"],"award-info":[{"award-number":["PSI2014-55087-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Exercise reduces cognitive deficits in traumatic brain injury (TBI), but early post-trauma exercise is often discouraged due to potential harm. The purpose was to evaluate the interaction between pre- and post-injury physical exercise on cognition, neuronal survival and inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Rats were either sham-operated and kept sedentary (Sham) or subjected to controlled cortical impact injury and then distributed into sedentary (Tbi), pre-injury exercise (Pre-Tbi), post-injury exercise with early (24\u2009hours, Tbi-early) or late (6\u2009days, Tbi-late) onset, and a combination of pre- and post-injury exercise with early (Pre-Tbi-early) or late (Pre-Tbi-late) onset. Object recognition memory, hippocampal volume, neuronal survival (NeuN\n                      <jats:sup>+<\/jats:sup>\n                      ) in the hippocampus and perirhinal cortex, and microglial activity (Iba-1) in the hippocampus were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All exercise conditions, except TBI-early, attenuated the significant memory impairment at 24-hour retention caused by TBI. Additionally, Pre-TBI-early treatment led to memory improvement at 3-hour retention. Pre-TBI reduced neuronal death and microglial activation in the hippocampus. TBI-late, but not TBI-early, mitigated hippocampal volume loss, loss of mature neurons in the hippocampus, and inflammation. Combining pre-injury and early-onset exercise reduced memory deficits but did not affect neuronal death or microglial activation. Combining pre-injury and late-onset exercise had a similar memory-enhancing effect than late post-injury treatment alone, albeit with reduced effects on neuronal density and neuroinflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Pre-TBI physical exercise reduces the necessary onset delay of post-TBI exercise to obtain cognitive benefits, yet the exact mechanisms underlying this reduction require further research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15459683241270023","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T02:55:55Z","timestamp":1723690555000},"page":"715-728","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Treating Traumatic Brain Injury with Exercise: Onset Delay and Previous Training as Key Factors Determining its Efficacy"],"prefix":"10.1177","volume":"38","author":[{"given":"Tanit","family":"S\u00e1nchez-Mart\u00edn","sequence":"first","affiliation":[{"name":"Departament de Psicobiologia i de Metodologia de les Ci\u00e8ncies de la Salut, Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Costa-Miserachs","sequence":"additional","affiliation":[{"name":"Departament de Psicobiologia i de Metodologia de les Ci\u00e8ncies de la Salut, Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margalida","family":"Coll-Andreu","sequence":"additional","affiliation":[{"name":"Departament de Psicobiologia i de Metodologia de les Ci\u00e8ncies de la Salut, Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Portell-Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Departament de Psicobiologia i de Metodologia de les Ci\u00e8ncies de la Salut, Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soleil","family":"Garc\u00eda-Brito","sequence":"additional","affiliation":[{"name":"Departament de Psicobiologia i de Metodologia de les Ci\u00e8ncies de la Salut, Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2511-8788","authenticated-orcid":false,"given":"Meritxell","family":"Torras-Garcia","sequence":"additional","affiliation":[{"name":"Departament de Psicobiologia i de Metodologia de les Ci\u00e8ncies de la Salut, Institut de Neuroci\u00e8ncies, Universitat Aut\u00f2noma de Barcelona, Bellaterra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,14]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3171\/2017.10.JNS17352"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2013.11.004"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2013.29"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968310397206"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2022.114204"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X241234770"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-160687"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2019.00135"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000754"},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","unstructured":"Silverberg ND Otamendi T. 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