{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:02:08Z","timestamp":1777942928450,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"8","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["K01HD092556"],"award-info":[{"award-number":["K01HD092556"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ClinicalTrials.gov","award":["NCT03819764"],"award-info":[{"award-number":["NCT03819764"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Physical, cognitive, and psychosocial impairments experienced by individuals post-stroke detrimentally impact health-related quality of life (HRQoL). Rehabilitation interventions targeting the recovery of motor function aim to improve community reintegration and HRQoL. Aerobic exercise has also been shown to have global effects in individuals post-stroke, positively affecting motor and mood-related outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine the effects of forced-rate aerobic exercise (FE) coupled with upper extremity repetitive task practice (RTP) on HRQoL and mood in individuals post-stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A rater blinded randomized clinical trial was conducted. Individuals \u22656\u2009months post-stroke received 90-minute sessions of FE+RTP or time-matched RTP alone, 3\u00d7\/week for 8\u2009weeks. The Stroke Impact Scale (SIS), Patient-Reported Outcomes Measurement Information System (PROMIS-29), and Centers For Epidemiology Studies-Depression Scale (CES-D) were administered at baseline, end of treatment (EOT), EOT+6\u2009months, and EOT+12\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Sixty participants enrolled in the study and 57 completed the self-reported questionnaires (FE\u2009+\u2009RTP, N\u2009=\u200929; RTP alone, N\u2009=\u200928). Both groups improved significantly at each time point in the following SIS domains: physical problems, feelings, activities of daily living, mobility, hand use, meaningful activities, and overall recovery; and in the participation domain of PROMIS-29. Depressive symptomology as measured by CES-D improved from baseline to EOT+6. There were no significant group differences in any of the outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Both interventions were comparably effective in improving HRQoL despite the FE+RTP group receiving only half the dose of RTP compared to the control group (RTP only). Improvements were maintained up to 1\u2009year post-intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15459683251338784","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T08:06:08Z","timestamp":1747901168000},"page":"591-601","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Task Practice With and Without Aerobic Exercise Improves Health-related Quality of Life and Social Participation Post-stroke: A Randomized Clinical Trial"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9094-9740","authenticated-orcid":false,"given":"Susan M.","family":"Linder","sequence":"first","affiliation":[{"name":"Cleveland Clinic, Department of Physical Medicine and Rehabilitation, Cleveland, OH, USA"},{"name":"Cleveland Clinic, Department of Biomedical Engineering, Lerner Research Institute, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Bischof-Bockbrader","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Department of Physical Medicine and Rehabilitation, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2734-4849","authenticated-orcid":false,"given":"Ozlenen Eylul","family":"Ince Hocaoglu","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Department of Physical Medicine and Rehabilitation, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Bethoux","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Department of Physical Medicine and Rehabilitation, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Davidson","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Concussion Center, Neurologic Institute, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donayja","family":"Harris","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Department of Physical Medicine and Rehabilitation, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4930-2168","authenticated-orcid":false,"given":"Yadi","family":"Li","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland, OH, USA"},{"name":"Cleveland Clinic, Center for Outcomes Research and Evaluation, Neurological Institute, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brittany","family":"Lapin","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland, OH, USA"},{"name":"Cleveland Clinic, Center for Outcomes Research and Evaluation, Neurological Institute, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay L.","family":"Alberts","sequence":"additional","affiliation":[{"name":"Cleveland Clinic, Department of Biomedical Engineering, Lerner Research Institute, Cleveland, OH, USA"},{"name":"Cleveland Clinic, Concussion Center, Neurologic Institute, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000950"},{"issue":"1","key":"e_1_3_2_3_2","first-page":"841","article-title":"Influence of post-stroke depression on functional independence in activities of daily living","volume":"29","author":"Ezema CI","year":"2019","unstructured":"Ezema CI, Akusoba PC, Nweke MC, Uchewoke CU, Agono J, Usoro G. Influence of post-stroke depression on functional independence in activities of daily living. Ethiop J Health Sci. 2019;29(1):841-846.","journal-title":"Ethiop J Health Sci"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-1331.2001.00182.x"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.3109\/09638288.2014.974834"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2020.06.011"},{"issue":"1","key":"e_1_3_2_7_2","first-page":"23","article-title":"Post-stroke depression: an update","volume":"30","author":"Esparrago Llorca G","year":"2015","unstructured":"Esparrago Llorca G, Castilla-Guerra L, Fernandez Moreno MC, Ruiz Doblado S, Jimenez Hernandez MD. Post-stroke depression: an update. Neurologia. 2015;30(1):23-31.","journal-title":"Neurologia"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-017-0686-6"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.21037\/atm-22-5443"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000383"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.2522\/ptj.20130053"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.2165\/11534530-000000000-00000"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2018.11.011"},{"issue":"1","key":"e_1_3_2_14_2","article-title":"Forced aerobic exercise preceding task practice improves motor recovery post-stroke","volume":"70","author":"Linder SM","year":"2017","unstructured":"Linder SM, Rosenfeldt AB, Dey T, Alberts JL. Forced aerobic exercise preceding task practice improves motor recovery post-stroke Am J Occup Ther. 2017;70(1):7102290020p1-7102290020p9.","journal-title":"Am J Occup Ther"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968319862557"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00594.2018"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2016.04.054"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004826"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2024.01.018"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1310\/BRHX-PKTA-0TUJ-UYWT"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-018-1842-3"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/09638288.2015.1102337"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-010-9597-5"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-022-03149-4"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.118.004753"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLR.0000062554.74615.4C"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1080\/10749357.2022.2026280"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/oti.275"},{"key":"e_1_3_2_29_2","volume-title":"Upper-Extremity Task-Specific Training After Stroke or Disability","author":"Lang CE","year":"2014","unstructured":"Lang CE, Birkenmeier RL. Upper-Extremity Task-Specific Training After Stroke or Disability. AOTA Press; 2014."},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968310361957"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24734"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1177\/15459683241233577"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1080\/10749357.2023.2259167"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1177\/02692155241302765"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106322"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000001738"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2023.06.007"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2021-326615"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025119931010"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/sc.2008.82"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1089\/jpm.2023.0061"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/jan.14722"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2019.1699173"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1080\/09638288.2017.1381186"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphys.2018.08.004"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000098"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.2196\/40213"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002652"}],"container-title":["Neurorehabilitation and Neural Repair"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15459683251338784","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15459683251338784","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15459683251338784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:11:03Z","timestamp":1777705863000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15459683251338784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,22]]},"references-count":47,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1177\/15459683251338784"],"URL":"https:\/\/doi.org\/10.1177\/15459683251338784","relation":{},"ISSN":["1545-9683","1552-6844"],"issn-type":[{"value":"1545-9683","type":"print"},{"value":"1552-6844","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,22]]}}}