{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:37:45Z","timestamp":1791333465014,"version":"4.3.1"},"reference-count":38,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Huizhi Ascent Project of Xuanwu Hospital","award":["HZ2021ZCLJ005"],"award-info":[{"award-number":["HZ2021ZCLJ005"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.82402499"],"award-info":[{"award-number":["No.82402499"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The cerebellar cortex has gradually become a promising therapeutic target for improving motor recovery post-cerebral infarction, potentially dependent on the structural integrity of motor-related corticocerebellar pathways (CCP). However, the relationship between the imaging markers of motor-related CCP and motor prognosis remains inadequately explored. Utilizing diffusion tensor imaging (DTI), this study aims to longitudinally assess the role of motor-related CCP in predicting motor recovery for both upper and lower extremities following cerebral infarction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-nine patients with right middle cerebral artery (MCA) infarction underwent 2 DTI scans 7 to 14 and 30\u2009days after onset, and 29 age-sex matched controls received 1 scan. Fractional anisotropy (FA) values were measured for corticospinal tract (CST) and CCP (cortico-pontocerebellar tract, CPCT; dentate-thalamocortical tract, DTCT; dorsal-spinocerebellar tract, DSCT). Multivariate regression analyses were performed to examine the relationships between DTI parameters and Fugl-Meyer Assessment (FMA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to the control group, FA and FA asymmetry index (FA-AI) of CST, DTCT, and DSCT on the affected side were significantly reduced. In the linear regression model, the decreased FA-AI of DTCT was a strong predictor for upper FMA (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      <jats:sub>\n                        <jats:italic>adj<\/jats:italic>\n                      <\/jats:sub>\n                      \u2009=\u20090.271,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.022), while the FA-AI of DSCT independently predicted lower limb FMA (\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      <jats:sub>\n                        <jats:italic>adj<\/jats:italic>\n                      <\/jats:sub>\n                      \u2009=\u20090.400,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.019).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients of MCA infarction, FA-AI of motor-related CCP may be a valuable imaging indicator for predicting motor outcomes. The DTI-assessed structural integrity of the cerebellar ascending fiber tracts (DTCT and DSCT) may correlate with the motor recovery of the upper and lower extremities, respectively.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15459683251351879","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T07:35:16Z","timestamp":1751096116000},"page":"765-775","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Prediction of Motor Recovery after Subacute Cerebral Infarction: Role of Corticocerebellar Pathway Integrity"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6441-3557","authenticated-orcid":false,"given":"Jing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi-Xiao","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao-Zhen","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Lin","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0425-3921","authenticated-orcid":false,"given":"Jie","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China"},{"name":"Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,6,28]]},"reference":[{"key":"e_1_3_3_2_2","article-title":"Management of acute ischemic stroke","volume":"368","author":"Phipps MS","year":"2020","unstructured":"Phipps MS, Cronin CA. 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