{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:24:25Z","timestamp":1791246265324,"version":"4.1.0"},"reference-count":34,"publisher":"SAGE Publications","issue":"10","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["IZLIZ3_200275"],"award-info":[{"award-number":["IZLIZ3_200275"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PZ00P3_186101"],"award-info":[{"award-number":["PZ00P3_186101"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EU Program Horizon2020","award":["681094"],"award-info":[{"award-number":["681094"]}]},{"name":"Wings for Life"},{"name":"Wyss Zurich"},{"name":"Swiss Paraplegic Foundation"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The aim of clinical trials for spinal cord injury (SCI) is to improve everyday-life activity outcomes, which requires reliable methods for monitoring patient activity. This study evaluates sensor-derived activity metrics in comparison to established clinical assessment methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Wearable inertial sensors collected data from 69 individuals with acute, traumatic cervical SCI participating in the Nogo-A Inhibition in Spinal Cord Injury trial (NCT03935321), a phase 2b, multicenter, randomized, placebo-controlled trial. During inpatient rehabilitation, participants wore up to 5 inertial sensors for up to 3 consecutive days each week. An estimation of average daily energy expenditure (EE) was used as an indicator of physical activity and compared to the recovery of Upper Extremity Motor Scores (UEMS) and Spinal Cord Independence Measures (SCIM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Participants in the\n                      <jats:italic>verum<\/jats:italic>\n                      (n\u2009=\u200941; 59.4%) and placebo (n\u2009=\u200928; 40.6%) groups showed similar initial activity levels, however, the\n                      <jats:italic>verum<\/jats:italic>\n                      group exhibited a significantly greater weekly increase in average daily EE (\u0394EE\u2009=\u200911.6\u2009kcal\/day\/week, 95% CI [1.5, 21.8],\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.025). In contrast, no significant group differences were observed in changes in UEMS (\u0394UEMS\u2009=\u20090.1\/week, 95% CI [\u22120.2, 0.3],\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.603) or SCIM (\u0394SCIM\u2009=\u20090.2, per week 95% CI [\u22120.7, 1.1],\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.644).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Continuous sensor-based activity monitoring offers objective and sensitive insights into changes in physical capabilities, effectively complementing periodic clinical assessments. Thus, sensor-derived outcome measures offer potential for improving the evaluation of clinical studies in individuals with SCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trail Registration:<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\">https:\/\/clinicaltrials.gov<\/jats:ext-link>\n                      ; NCT03935321.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15459683251352556","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T11:33:22Z","timestamp":1752147202000},"page":"814-825","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Feasibility and Sensitivity of Wearable Sensors for Daily Activity Monitoring in Spinal Cord Injury Trials"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3818-259X","authenticated-orcid":false,"given":"Melina","family":"Giagiozis","sequence":"first","affiliation":[{"name":"Spinal Cord Injury Center, University Hospital Balgrist, Zurich, Switzerland"},{"name":"Department of Health Sciences and Technology (D-HEST), ETH Zurich, Zurich, Switzerland"},{"name":"Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Lerch","sequence":"additional","affiliation":[{"name":"Spinal Cord Injury Center, University Hospital Balgrist, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita D.","family":"Linke","sequence":"additional","affiliation":[{"name":"Spinal Cord Injury Center, University Hospital Balgrist, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine 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