{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:18:53Z","timestamp":1792685933650,"version":"4.5.0"},"reference-count":49,"publisher":"SAGE Publications","issue":"11","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100007229","name":"Special Research Fund","doi-asserted-by":"crossref","award":["BOF20BL15"],"award-info":[{"award-number":["BOF20BL15"]}],"id":[{"id":"10.13039\/501100007229","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>High-intensity interval training (HIIT) has emerged as a potentially effective exercise promoting functional recovery post-stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This study examined the efficacy of adding HIIT cycling vs. combining unloaded cycling (SHAM) to conventional physiotherapy on exercise capacity, functional ability, disability level, and health-related quality of life (HRQoL) early post-stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Forty-four acute stroke survivors were randomly assigned to the HIIT cycling or SHAM group for 6 weeks of exercise training, 3\u2009days\/week. The primary outcome was exercise capacity (peak work load [WRpeak]) measured by a maximal exercise test. Secondary outcomes included balance: Berg Balance Scale, walking ability: 6-minute and 10-meter walk tests (6MWT and 10mWT), lower-extremity muscle strength: 5-Repetition Sit-To-Stand test, disability level: modified Rankin Scale (mRS), and HRQoL by EuroQOL 5-dimension questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The 2-way factorial analysis of variance showed a significant interaction of time\u2009\u00d7\u2009group on WRpeak (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001), 6MWT (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001), 10mWT (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001), and mRS (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.012). The significant interaction indicates that the change in WRpeak (mean +17.7\u2009W [95% CI, 10.2-25.1]), 6MWT (mean +126.8\u2009m [77.9-175.7]), 10mWT (mean +0.5\u2009m\/s [0.3-0.7]), and mRS (mean \u22120.7 point [\u22121.2 to \u22120.2]) after 6-week of training was significantly greater for HIIT cycling versus SHAM. These changes are also significantly greater in the HIIT group vs the SHAM group up to 6\u2009months (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001) post-training.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In individuals with acute stroke, individuals, combining HIIT cycling with conventional physiotherapy significantly maximizes recovery of exercise capacity and walking ability, and reduces the level of disability early post-stroke, compared to SHAM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Protocol Registration number:<\/jats:title>\n                    <jats:p>NCT06179173<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15459683251356969","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T13:39:00Z","timestamp":1754919540000},"page":"892-905","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Exercise Intensity Matters in the Rehabilitation of Stroke in the Acute Stage: A Randomized Controlled Trial"],"prefix":"10.1177","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1315-8774","authenticated-orcid":false,"given":"Elogni Renaud","family":"Amanzonw\u00e9","sequence":"first","affiliation":[{"name":"UHasselt, Faculty of Rehabilitation Sciences, BIOMED-REVAL-Rehabilitation Research Centre, Hasselt University, Diepenbeek, Belgium"},{"name":"Unit of Neurology and NeuroRehabilitation, University Hospital of Parakou, Parakou, Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e8nad\u00e9 In\u00e8s","family":"Noukpo","sequence":"additional","affiliation":[{"name":"UHasselt, Faculty of Rehabilitation Sciences, BIOMED-REVAL-Rehabilitation Research Centre, Hasselt University, Diepenbeek, Belgium"},{"name":"Unit of Neurology and NeuroRehabilitation, University Hospital of Parakou, Parakou, Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Adoukonou","sequence":"additional","affiliation":[{"name":"Unit of Neurology and NeuroRehabilitation, University Hospital of Parakou, Parakou, Benin"},{"name":"ENATSE, National School of Public Health and Epidemiology, Universit\u00e9 de Parakou, Parakou, Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Bonnech\u00e8re","sequence":"additional","affiliation":[{"name":"UHasselt, Faculty of Rehabilitation Sciences, BIOMED-REVAL-Rehabilitation Research Centre, Hasselt University, Diepenbeek, Belgium"},{"name":"Technology-Supported and Data-Driven Rehabilitation, Data Sciences Institute, Hasselt University, Diepenbeek, Belgium"},{"name":"Department of PXL-Healthcare, PXL University of Applied Sciences and Arts, Hasselt, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5680-5495","authenticated-orcid":false,"given":"Peter","family":"Feys","sequence":"additional","affiliation":[{"name":"UHasselt, Faculty of Rehabilitation Sciences, BIOMED-REVAL-Rehabilitation Research Centre, Hasselt University, Diepenbeek, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Hansen","sequence":"additional","affiliation":[{"name":"UHasselt, Faculty of Rehabilitation Sciences, BIOMED-REVAL-Rehabilitation Research Centre, Hasselt University, Diepenbeek, Belgium"},{"name":"Heart Centre Hasselt, Jessa Hospital, Hasselt, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9117-7191","authenticated-orcid":false,"given":"Oy\u00e9n\u00e9","family":"Kossi","sequence":"additional","affiliation":[{"name":"UHasselt, Faculty of Rehabilitation Sciences, BIOMED-REVAL-Rehabilitation Research Centre, Hasselt University, Diepenbeek, Belgium"},{"name":"Unit of Neurology and NeuroRehabilitation, University Hospital of Parakou, Parakou, Benin"},{"name":"ENATSE, National School of Public Health and Epidemiology, Universit\u00e9 de Parakou, Parakou, Benin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/17474930221147164"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.4102\/sajp.v77i1.1559"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2002.36395"},{"key":"e_1_3_3_5_2","unstructured":"Goldstein RE. 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