{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:02:16Z","timestamp":1777942936865,"version":"3.51.4"},"reference-count":66,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T00:00:00Z","timestamp":1766016000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000887","name":"Huntington\u2019s Disease Society of America","doi-asserted-by":"publisher","award":["Human Biology Project"],"award-info":[{"award-number":["Human Biology Project"]}],"id":[{"id":"10.13039\/100000887","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Examine cortical activation patterns in Huntington\u2019s disease (HD) under single-task (ST) and dual-task (DT) balance conditions compared to controls using portable functional near-infrared spectroscopy (fNIRS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Individuals with HD have difficulty multitasking while performing balance tasks, so previously automatic tasks may require more attentional resources to maintain stability and prevent falls. Our understanding of the neural mechanisms underlying the relationship between impaired cognition and balance in HD is minimal. fNIRS provides a noninvasive means to functionally image the brain under ecologically valid conditions to understand the neural underpinnings of impaired balance in HD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighteen HD (56.2\u2009\u00b1\u20099.8\u2009years) and 20 age-matched control participants (57.4\u2009\u00b1\u200911.2\u2009years) completed ST\/ DT balance testing with eyes open (EO) or eyes closed (EC) wearing inertial sensors and fNIRS to collect spatiotemporal balance variables with concurrent prefrontal (PFC) and posterior parietal (PPC) cortical activity monitoring. The cognitive DT was the Controlled Oral Word Association Test during 3, 30-second trials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Individuals with HD had significantly lower PPC activity during the EO DT condition compared to controls (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.007). Unlike controls, there were no differences in PFC or PPC activation across balance conditions in HD, despite significantly worsening postural sway during DT conditions (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that individuals with HD are unable to increase cortical activation during challenging DT conditions suggesting a recruitment ceiling was reached during ST conditions. Furthermore, individuals with HD may not be able to increase cortical recruitment in response to increasing task difficulty.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15459683251395713","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T09:39:53Z","timestamp":1766050793000},"page":"25-36","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cortical Correlates of Balance During Single and Dual Tasks in Huntington\u2019s Disease: A Preliminary fNIRS Study"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7317-6810","authenticated-orcid":false,"given":"Nicollette L.","family":"Purcell","sequence":"first","affiliation":[{"name":"Department of Anatomy and Cell Biology, Rush University, Chicago, IL, USA"},{"name":"Illinois College of Optometry, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6846-9372","authenticated-orcid":false,"given":"Samuel","family":"Stuart","sequence":"additional","affiliation":[{"name":"Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne, UK"},{"name":"Department of Neurology, Oregon Health &amp; Science University, Portland, OR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Vitorio","sequence":"additional","affiliation":[{"name":"Department of Sport, Exercise and Rehabilitation, Northumbria University, Newcastle upon Tyne, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily C.","family":"Timm","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Rush University, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah A.","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Rush University, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9395-2980","authenticated-orcid":false,"given":"Christa","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Rush University, Chicago, IL, USA"},{"name":"The Ken and Ruth Davee Department of Neurology, Movement Disorders Division, Northwestern University, Chicago, IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bichun","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Neurological Sciences, Rush University, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan A.","family":"O\u2019Keefe","sequence":"additional","affiliation":[{"name":"Departments of Anatomy and Cell Biology and Neurological Sciences, Rush University, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,18]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70245-3"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-71779-1_1"},{"key":"e_1_3_2_4_2","unstructured":"Ajitkumar A De Jesus O. 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