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Transcranial direct current stimulation (TDCS) may enhance UE recovery, but response variability remains a challenge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This randomized, double-blinded feasibility and pilot clinical trial evaluated effects of patient-tailored TDCS versus sham on UE recovery in subacute stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with subacute ischemic stroke and UE impairment were randomized to receive either anodal TDCS or sham stimulation, during UE rehabilitation 3 times weekly for 4\u2009weeks. Electrode placement was patient-tailored and optimized using electric field modeling and targeted the ipsilesional primary motor hand area (M1-HAND). Primary outcome was Fugl-Meyer Assessment of UE (FMA-UE) score at end-of-intervention (EOT) and 12-weeks follow-up. Feasibility and exploratory clinical outcomes were also assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      24 participants were randomized into real (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200912, mean age 63\u2009years) and sham TDCS (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200912, mean age 68\u2009years). FMA-UE improved at EOT in both groups, but improvement was significantly larger in the real TDCS group (mean difference 4.5\u2009points, 95% confidence interval (CI) \u22125.34-14.31,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009=\u2009.011). The differences diminished at 12-week follow-up. Median compliance was 95.8 and 100%, for real- and sham-TDCS groups, respectively, with no severe adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patient-tailored anodal TDCS over the ipsilesional M1-HAND may boost recovery of UE impairment in subacute stroke versus sham TDCS. This trial identified a clinically feasible framework for optimizing protocols of patient-tailored TDCS for larger-scale stroke trials. Despite the complex trial setup, the favorable safety profile supports future large-scale studies with improved stratification by UE impairment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15459683251395731","type":"journal-article","created":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T02:56:52Z","timestamp":1768791412000},"page":"199-213","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Patient-Tailored Transcranial Direct Current Stimulation Versus Sham for Upper-Extremity Rehabilitation in Subacute Stroke Patients: A Feasibility and Pilot Trial"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7071-1399","authenticated-orcid":false,"given":"Mia","family":"Kolmos","sequence":"first","affiliation":[{"name":"Neurovascular Research Unit, Department of Neurology, Copenhagen University Hospital \u2013 Herlev and Gentofte, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3167-7261","authenticated-orcid":false,"given":"Katrine Lyders","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy and Occupational Therapy, Herlev Gentofte Hospital, Copenhagen University, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0981-0723","authenticated-orcid":false,"given":"Markus Harboe","family":"Olsen","sequence":"additional","affiliation":[{"name":"Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Neuroanaesthesiology, The Neuroscience Centre, Copenhagen University Hospital \u2013 Rigshospitalet, Copenhagen, 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