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Although CAF has been associated with impairments in these domains, the unique and combined contributions of motor, cognitive, psychological, and neural factors remain unclear. This study used a comprehensive approach to identify behavioral and neural predictors of CAF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Forty-three individuals with MS completed motor, cognitive, and psychological assessments, and underwent a structural magnetic resonance imaging scan. Linear regression models examined domain-specific predictors of CAF, controlling for disease severity. A discriminant function analysis (DFA) evaluated the combined predictive value of all variables in classifying individuals into high versus low CAF groups based on a median split.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CAF was significantly associated with impairments across all behavioral domains (|\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      |\u2009=\u2009.32-.78). Regression models explained 57% to 74% of variance in CAF. Greater physical fatigue (\u03b2\u2009=\u2009.46), slower backward walking speed (\u03b2\u2009=\u2009\u2212.41), slower processing speed (\u03b2\u2009=\u2009\u2212.44), impaired task-switching (\u03b2\u2009=\u2009.32), higher anxiety (\u03b2\u2009=\u2009.38), and avoidance behavior (\u03b2\u2009=\u2009.58) predicted greater CAF. Hippocampal and cerebellar volumes were not significant predictors after accounting for disease severity. DFA classified participants with high accuracy (73.9% low CAF; 65.0% high CAF).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>CAF in MS reflects a complex interplay of physical, cognitive, and emotional factors. While structural brain measures were not independently predictive, the combined influence of motor, cognitive, and psychological factors highlight the need for multidomain assessments and treatments to reduce CAF and its negative consequences in MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15459683251412284","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:29:58Z","timestamp":1771234198000},"page":"265-277","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Motor, Cognitive, Psychological, and Neural Predictors of Concern About Falling in Persons With Multiple Sclerosis"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-5752","authenticated-orcid":false,"given":"Taylor N.","family":"Takla","sequence":"first","affiliation":[{"name":"Neuroimaging and Neurorehabilitation Laboratory, Wayne State University, Detroit, MI, USA"},{"name":"Translational Neuroscience Program, Wayne State University, Detroit, MI, USA"},{"name":"Department of Psychiatry &amp; Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1151-7000","authenticated-orcid":false,"given":"Patrick G.","family":"Monaghan","sequence":"additional","affiliation":[{"name":"Neuroimaging and Neurorehabilitation Laboratory, Wayne State University, Detroit, MI, USA"},{"name":"Department of Health Care Sciences, Wayne State University, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5678-8431","authenticated-orcid":false,"given":"Maryam M.","family":"Abbawi","sequence":"additional","affiliation":[{"name":"Neuroimaging and Neurorehabilitation Laboratory, Wayne State University, Detroit, MI, USA"},{"name":"Translational Neuroscience Program, Wayne State University, Detroit, MI, USA"},{"name":"Department of Psychiatry &amp; Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4234-910X","authenticated-orcid":false,"given":"Merrill R.","family":"Landers","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, University of Nevada, Las Vegas, NV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0771-6795","authenticated-orcid":false,"given":"Hilary A.","family":"Marusak","sequence":"additional","affiliation":[{"name":"Translational Neuroscience Program, Wayne State University, Detroit, MI, USA"},{"name":"Department of Psychiatry &amp; Behavioral Neurosciences, School of Medicine, Wayne State University, Detroit, MI, USA"},{"name":"Merrill Palmer Skillman Institute for Child and Family Development, Wayne State University, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9980-154X","authenticated-orcid":false,"given":"Ana M.","family":"Daugherty","sequence":"additional","affiliation":[{"name":"Translational Neuroscience Program, Wayne State University, Detroit, MI, USA"},{"name":"Department of Psychology, Wayne State University, Detroit, MI, USA"},{"name":"Institute of Gerontology, Wayne State University, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4548-1077","authenticated-orcid":false,"given":"Nora E.","family":"Fritz","sequence":"additional","affiliation":[{"name":"Neuroimaging and Neurorehabilitation Laboratory, Wayne State University, Detroit, MI, USA"},{"name":"Translational Neuroscience Program, Wayne State University, Detroit, MI, USA"},{"name":"Department of Health Care Sciences, Wayne State University, Detroit, MI, USA"},{"name":"Department of Neurology, Wayne State University, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514564487"},{"key":"e_1_3_3_3_2","article-title":"Cognitive impairment in multiple sclerosis: a forgotten disability remembered","volume":"14","author":"Rahn K","year":"2012","unstructured":"Rahn K, Slusher B, Kaplin A. 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