{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:47:36Z","timestamp":1782366456759,"version":"3.54.5"},"reference-count":25,"publisher":"SAGE Publications","issue":"7","license":[{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T00:00:00Z","timestamp":1777075200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100000261","name":"Multiple Sclerosis Society of Canada","doi-asserted-by":"publisher","award":["EGID3185"],"award-info":[{"award-number":["EGID3185"]}],"id":[{"id":"10.13039\/501100000261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Neurorehabil Neural Repair"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>RehaCom, a computerized cognitive rehabilitation program for people with multiple sclerosis (PwMS), has been studied primarily in relation to treatment \u201cdose\u201d (duration, frequency, and adherence), with less focus on which training modules drive improvement or which participant factors predict responsiveness. This secondary analysis of the CogEx trial investigated whether progression within specific RehaCom modules was associated with processing speed improvement, measured by the SDMT, and whether baseline characteristics predicted response in participants with progressive MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 153 participants completed 12\u2009weeks of RehaCom training across 5 attention-based modules. Cognition was assessed at baseline, 12\u2009weeks, and 6\u2009months using the SDMT. Correlation and regression analyses evaluated associations between module progression and cognitive outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Progression correlated significantly with SDMT improvement in 4 modules, with the strongest effects for Attention\/Concentration (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u2009.37,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001) and Divided Attention-2 (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      \u2009=\u2009.36,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      \u2009&lt;\u2009.001). Higher baseline SDMT, higher premorbid IQ, older age, and greater module progression independently predicted better SDMT performance at12-weeks (adjusted\n                      <jats:italic toggle=\"yes\">R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u2009.73). At 6\u2009months, higher baseline SDMT, greater progression in Attention\/Concentration and Divided Attention-2, older age, and female sex predicted better SDMT performance (adjusted\n                      <jats:italic toggle=\"yes\">R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u2009.71).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Processing speed gains in progressive MS were related to both module-specific progression and participant characteristics, supporting a precision approach to cognitive rehabilitation that tailors training content to individual cognitive profiles. This study is a secondary analysis of the CogEx trial (ClinicalTrials.gov Identifier: NCT03679468;\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03679468\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03679468<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/15459683261432556","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:05:31Z","timestamp":1777107931000},"page":"575-586","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Looking Beyond Dose: Identifying Responders and Non-Responders to RehaCom Computerized Cognitive Rehabilitation in Progressive MS\u2014The CogEx Study"],"prefix":"10.1177","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8553-0440","authenticated-orcid":false,"given":"Cecilia","family":"Meza","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, ON, Canada"},{"name":"Division of Neurology, St. Michael\u2019s Hospital, Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3143-682X","authenticated-orcid":false,"given":"Roberto S.","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Neurology, Section on Statistical Planning and Analysis, Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana L.","family":"Costa","sequence":"additional","affiliation":[{"name":"Kessler Foundation, Neuropsychology and Neuroscience Center, East Hanover, NJ, USA"},{"name":"Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, Newark, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1088-110X","authenticated-orcid":false,"given":"Amber","family":"Salter","sequence":"additional","affiliation":[{"name":"Department of Neurology, Section on Statistical Planning and Analysis, Dallas, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2943-7567","authenticated-orcid":false,"given":"Nancy D.","family":"Chiaravalloti","sequence":"additional","affiliation":[{"name":"Kessler Foundation, Neuropsychology and Neuroscience Center, East Hanover, NJ, USA"},{"name":"Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, Newark, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Pia","family":"Amato","sequence":"additional","affiliation":[{"name":"NEUROFARBA Department, Section of Neurosciences, University of Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giampaolo","family":"Brichetto","sequence":"additional","affiliation":[{"name":"Scientific Research Area, Italian Multiple Sclerosis Foundation (FISM), Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Chataway","sequence":"additional","affiliation":[{"name":"Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, UK"},{"name":"National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Cutter","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Alabama at Birmingham, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4132-2789","authenticated-orcid":false,"given":"Ulrik","family":"Dalgas","sequence":"additional","affiliation":[{"name":"Department of Public Health, Exercise Biology, Aarhus University, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"DeLuca","sequence":"additional","affiliation":[{"name":"Kessler Foundation, Neuropsychology and Neuroscience Center, East Hanover, NJ, USA"},{"name":"Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, Newark, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Farrell","sequence":"additional","affiliation":[{"name":"Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, UK"},{"name":"National Institute for Health and Care Research, University College London Hospitals Biomedical Research Centre, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5680-5495","authenticated-orcid":false,"given":"Peter","family":"Feys","sequence":"additional","affiliation":[{"name":"REVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5485-0479","authenticated-orcid":false,"given":"Massimo","family":"Filippi","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy"},{"name":"Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy"},{"name":"Vita-Salute San Raffaele University, Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Freeman","sequence":"additional","affiliation":[{"name":"Faculty of Health, School of Health Professions, University of Plymouth, Devon, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Inglese","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, and Center of Excellence for Biomedical Research, University of Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Motl","sequence":"additional","affiliation":[{"name":"Department of Kinesiology and Nutrition, University of Illinois Chicago, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2358-4320","authenticated-orcid":false,"given":"Maria A.","family":"Rocca","sequence":"additional","affiliation":[{"name":"Neuroimaging 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Department of Psychiatry, University of Toronto, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"CogEx Research 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