{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:03:41Z","timestamp":1777943021235,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"1-2","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Laughing Youth Project of the China Oral Health Foundation","award":["A2023- 005"],"award-info":[{"award-number":["A2023- 005"]}]},{"name":"the Natural Science Foundation of Shandong Province","award":["ZR2022MH215 and ZR2024QC169"],"award-info":[{"award-number":["ZR2022MH215 and ZR2024QC169"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells and Development"],"published-print":{"date-parts":[[2026,1,1]]},"abstract":"<jats:p>\n                    This study investigates the effects of inflammation and orthodontic forces on the osteogenic differentiation of human dental follicle stem cells (hDFSCs) and their role in periodontal regeneration during orthodontic tooth movement (OTM) in periodontitis patients. Human DFSCs were exposed to interleukin-1\u03b2 (IL-1\u03b2) and orthodontic compressive force (OCF). Western blot and quantitative real-time polymerase chain reaction (qRT-PCR) assessed the expression of a disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS2), osteogenic markers, and ERK signaling components. ADAMTS2 overexpression (OE) plasmids and ERK activators were applied to explore the ADAMTS2\/ERK signaling axis. A mouse periodontitis model with OTM was developed for in\u00a0vivo evaluation. IL-1\u03b2 and OCF downregulated ALP, RUNX2, and ERK pathway-related proteins and decreased ADAMTS2 expression. OE of ADAMTS2 significantly enhanced ERK phosphorylation (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05), promoting osteogenic differentiation of hDFSCs. ERK pathway activation with C16-PAF partially reversed the suppression of osteogenic differentiation induced by IL-1\u03b2 and OCF. ADAMTS2\/ERK axis components and osteogenic markers were reduced on the compressed side of periodontal tissues in the PD+OTM group (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05). These findings suggest that ADAMTS2 regulates the osteogenic differentiation of hDFSCs via the ERK signaling pathway under IL-1\u03b2 and OCF stimulation, highlighting its potential as a therapeutic target for alveolar bone regeneration during OTM in periodontitis patients.\n                  <\/jats:p>","DOI":"10.1177\/15473287251400300","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T17:02:37Z","timestamp":1764349357000},"page":"23-34","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["ADAMTS2 Mediates Osteogenic Differentiation of Dental Follicle Stem Cells Under Compressive Stress and Inflammation"],"prefix":"10.1177","volume":"35","author":[{"given":"Zhe","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Orthodontics, The Affiliated Hospital of Qingdao University, Qingdao, China."},{"name":"School of Stomatology, Qingdao University, Qingdao, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, The Affiliated Hospital of Qingdao University, Qingdao, China."},{"name":"School of Stomatology, Qingdao University, Qingdao, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, The Affiliated Hospital of Qingdao University, Qingdao, China."},{"name":"School of Stomatology, Qingdao University, Qingdao, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmiao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, The Affiliated Hospital of Qingdao University, Qingdao, China."},{"name":"School of Stomatology, Qingdao University, Qingdao, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph22040624"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-025-06111-1"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-025-00356-w"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-025-00354-y"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11914-023-00774-x"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-019-0068-8"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.4248\/ijos.08032"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-024-03882-2"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515578908"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2011.09.068"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108752"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-020-01841-1"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25041986"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.04.001"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnab017"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051407"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231810673"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2025.0041"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0633-z"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.14550"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076353"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom12070959"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12251"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/1380851"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020625"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1469733"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034516686558"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01200"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/jper.20-0354"}],"container-title":["Stem 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