{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:45:15Z","timestamp":1782711915015,"version":"3.54.5"},"reference-count":36,"publisher":"SAGE Publications","issue":"3-4","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Natural Science Foundation General Project of Shanxi Province","award":["202203021211070"],"award-info":[{"award-number":["202203021211070"]}]},{"name":"Key Research and Development Projects of Shanxi Province","award":["201803d31144"],"award-info":[{"award-number":["201803d31144"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells and Development"],"published-print":{"date-parts":[[2026,2,1]]},"abstract":"<jats:p>\n                    Effective treatment options for steroid-refractory acute graft-versus-host disease (SR-aGVHD) remain limited. Mesenchymal stromal cells (MSCs) offer a promising therapeutic approach, but the optimal administration protocol is undefined. This retrospective cohort study investigated the impact of MSC infusion frequency on outcomes in patients with grade III\u2013IV SR-aGVHD who received umbilical cord-derived MSCs either once weekly (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 25) or three times weekly (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 18). The primary endpoints were overall response rate (ORR) and complete response (CR) at 28 days, and secondary endpoints included overall survival (OS) and changes in lymphocyte subsets. The thrice-weekly group demonstrated significantly superior ORR (77.8% vs. 48.0%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05) and CR rates (55.6% vs. 20.0%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05), with a particularly notable benefit in gastrointestinal aGVHD (ORR: 73.3% vs. 35.0%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05). Immunological analysis showed a more rapid and profound decline in CD3\n                    <jats:sup>+<\/jats:sup>\n                    CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in the thrice-weekly group (nadir: 21.16% vs. 52.09%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05; time to nadir: 10 vs. 21 days,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05). With a median follow-up of 423 days, the thrice-weekly regimen was associated with significantly improved 2-year OS (78.1% vs. 47.4%,\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.05). Despite the limitations of a retrospective design, these findings suggest that increased MSC infusion frequency might be associated with improved therapeutic efficacy and survival in severe SR-aGVHD. However, the potential confounding effect of cumulative dose cannot be excluded, and these results warrant validation in prospective randomized trials.\n                  <\/jats:p>","DOI":"10.1177\/15473287251413996","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T04:41:16Z","timestamp":1767760876000},"page":"80-87","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Thrice-Weekly Versus Once-Weekly Umbilical Cord Mesenchymal Stromal Cell Infusions for Steroid-Refractory Severe Acute Graft-Versus-Host Disease: A Retrospective Cohort Study"],"prefix":"10.1177","volume":"35","author":[{"given":"Ya-Qian","family":"Zhao","sequence":"first","affiliation":[{"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Ru","family":"Yu","sequence":"additional","affiliation":[{"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Chen","sequence":"additional","affiliation":[{"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01159-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/2040620713489842"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.04.005"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703032"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25839"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.05.004"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16104-7"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2006.07.004"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8722-5-19"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2007.06.021"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/20406207211072838"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-015-1915-9"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3250-8"},{"key":"e_1_3_3_15_2","first-page":"186","article-title":"The use of allogeneic mesenchymal stem cells in childhood steroid-resistant acute graft-versus-host disease: A retrospective study of a single-center experience","volume":"36","author":"Bozkurt C","year":"2019","unstructured":"Bozkurt C, , Kara\u00f6z E, , Adakl\u0131 Aksoy B, et al. 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