{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T03:34:44Z","timestamp":1794454484549,"version":"4.9.1"},"reference-count":53,"publisher":"SAGE Publications","issue":"19-20","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells and Development"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:p>Despite currently available treatment options for moderate-to-severe atopic dermatitis (AD), some patients fail to achieve adequate disease control. Emerging evidence suggests that mesenchymal stem cells (MSCs) may represent a promising therapeutic option. This systematic review and meta-analysis included four randomized controlled trials (RCTs) and one non-randomized clinical trial. Eligible studies evaluated patients with moderate-to-severe AD treated with MSCs derived from human umbilical cord blood, autologous adipose tissue, and allogeneic bone marrow. PubMed, Embase, and Cochrane were searched from inception to December 2025. Primary outcomes included the proportion of patients achieving \u226550% and \u226575% improvement from baseline in the Eczema Area and Severity Index (EASI) and safety outcomes. The meta-analysis included 236 participants. The pooled EASI-50 response rate at week 12 was 46.76% (95% confidence interval [CI]: 32.36% to 61.72%). EASI-75 response rates were 17.41% (95% CI: 5.56% to 43.03%) at week 12 and 23.97% (95% CI: 16.48% to 33.50%) at week 16. The pooled incidence of treatment-emergent adverse events was 26.86% (95% CI: 19.56% to 35.68%), with infections and infestations 7.97% (95% CI: 4.11% to 14.88%) and gastrointestinal disorders 3.52% (95% CI: 1.33% to 9.01%) being the most frequently reported. MSC-based therapy shows early promise as a potential treatment for moderate-to-severe AD, offering a possible alternative to traditional therapies. However, the current evidence is largely based on small clinical trials, underscoring the necessity for large-scale RCTs to establish the efficacy and safety of MSC-based therapy in broader patient populations.<\/jats:p>","DOI":"10.1177\/15473287261475857","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T05:20:08Z","timestamp":1786684808000},"page":"377-385","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["The Potential Role of Mesenchymal Stem Cell Therapy for Moderate-to-Severe Atopic Dermatitis: A Systematic Review and Meta-Analysis of Human Clinical Trials"],"prefix":"10.1177","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6737-9305","authenticated-orcid":false,"given":"Martin","family":"Cevallos-Cueva","sequence":"first","affiliation":[{"name":"School of Medicine, Universidad Central del Ecuador, Quito, Ecuador."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Ghanem","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taissa","family":"Novis","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Faculty of Medicine, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakshi","family":"Arora","sequence":"additional","affiliation":[{"name":"Guru Gobind Singh Medical College and Hospital, Faridkot, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najwaa","family":"Kirmani","sequence":"additional","affiliation":[{"name":"Dow Medical College, Karachi, Pakistan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00fcmeyye","family":"Akta\u015f","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Fern\u00e1ndez-Faith","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Dermatology, Nationwide Children\u2019s Hospital and The Ohio State University College of Medicine, Columbus, Ohio, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-29.6.587"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llaf233"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2024.06.001"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2025.05.1386"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2023.08.102"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2023.11.009"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.20639"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.14485"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2023.08.029"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00326"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.19-0333"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani13132215"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-023-03365-w"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094868"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.5455\/javar.2020.g453"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2401"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.15928"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2024.06.013"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-025-04763-y"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n160"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_3_3_25_1","volume-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 6.5","author":"Higgins JPT","year":"2024","unstructured":"24.Higgins JPT, , Thomas J, , Chandler J, et al. 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