{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:07:44Z","timestamp":1789052864402,"version":"build-2803163510"},"reference-count":39,"publisher":"SAGE Publications","issue":"19-20","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"the Fourth \"Qinghai Scholar\" Program","award":["2025-qhxz-fhn"],"award-info":[{"award-number":["2025-qhxz-fhn"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Stem Cells and Development"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:p>Bronchopulmonary dysplasia (BPD) is a major complication of prematurity with limited disease-modifying therapies. We evaluated umbilical cord-derived cell-based interventions for BPD and related complications in preterm infants. This Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020-based systematic review and meta-analysis were registered in PROSPERO. PubMed, Cochrane Library, Web of Science, CNKI, and Wanfang were searched from inception to June 14, 2026. Comparative clinical studies of umbilical cord-derived cell-based interventions in preterm infants at risk of or diagnosed with BPD were included. Outcomes included BPD, BPD severity, death, persistent pulmonary hypertension of the newborn (PPHN), patent ductus arteriosus (PDA), intraventricular hemorrhage (IVH), necrotizing enterocolitis (NEC), retinopathy of prematurity (ROP), late-onset sepsis (LOS), and adverse events (AEs). Bayesian random-effects meta-analysis used a binomial-normal hierarchical model to estimate pooled odds ratios (ORs), 95% credible intervals (CrIs), prediction intervals, and heterogeneity. Twelve studies were included. Umbilical cord-derived cell-based interventions showed a possible protective effect on overall BPD (OR, 0.48; 95% CrI, 0.14\u20131.20). Stronger associations were observed for severe BPD (OR, 0.17; 95% CrI, 0.01\u20130.85), moderate or severe BPD (OR, 0.28; 95% CrI, 0.09\u20130.70), and ROP stage \u22653 (OR, 0.17; 95% CrI, 0.02\u20130.65). No conclusive benefit or harm was observed for death, PPHN, PDA, IVH, NEC, or LOS. No treatment-related serious AEs were identified. However, prediction intervals were generally wide, and the certainty of evidence was low to very low for most outcomes. Umbilical cord-derived cell-based interventions may reduce the risk of moderate or severe BPD in preterm infants, with an additional potential benefit for ROP stage \u22653. Current evidence remains limited, and larger randomized trials with standardized outcomes and long-term follow-up are needed.<\/jats:p>","DOI":"10.1177\/15473287261479169","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T08:01:44Z","timestamp":1787212904000},"page":"386-396","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Umbilical Cord-Derived Cell-Based Interventions for Bronchopulmonary Dysplasia and Related Complications in Preterm Infants: A Bayesian Sparse-Data Meta-Analysis"],"prefix":"10.1177","volume":"35","author":[{"given":"Yonghao","family":"Wen","sequence":"first","affiliation":[{"name":"Stem Cell and Regenerative Medicine Laboratory, Affiliated Hospital of Qinghai University, Xining, China."},{"name":"Clinical Medical College of Qinghai University, Xining, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlong","family":"Duan","sequence":"additional","affiliation":[{"name":"Stem Cell and Regenerative Medicine Laboratory, Affiliated Hospital of Qinghai University, Xining, China."},{"name":"Clinical Medical College of Qinghai University, Xining, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Nie","sequence":"additional","affiliation":[{"name":"Clinical Medical College of Qinghai University, Xining, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siai","family":"Chen","sequence":"additional","affiliation":[{"name":"Clinical Medical College of Qinghai University, Xining, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Radiology, School of Medicine, Guangzhou First People\u2019s Hospital, South China University of Technology, Guangzhou, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjun","family":"Deng","sequence":"additional","affiliation":[{"name":"Stem Cell and Regenerative Medicine Laboratory, Affiliated Hospital of Qinghai University, Xining, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5313-5732","authenticated-orcid":false,"given":"Haining","family":"Fan","sequence":"additional","affiliation":[{"name":"Stem Cell and Regenerative Medicine Laboratory, Affiliated Hospital of Qinghai University, Xining, China."},{"name":"Qinghai Research Key Laboratory for Echinococcosis, Xining, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(23)00878-4"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6780"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000497422"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2025-106960"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0127-7"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25381"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.01.043"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2026.03.004"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1301927"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.19-0193"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.101844"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.12.011"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.19-0106"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.20-0330"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1761"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.6381"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1370"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rec.2021.07.010"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5928"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-45"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1673-5501.2020.04.015"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18073492"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_3_2_25_1","first-page":"921","article-title":"Autologous cord blood transfusion in preterm infants\u2014could its humoral effect be the kez to control prematurity-related complications? 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