{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T10:51:27Z","timestamp":1782211887712,"version":"3.54.5"},"reference-count":29,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T00:00:00Z","timestamp":1773619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","award":["2018\/00955-4"],"award-info":[{"award-number":["2018\/00955-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006303","name":"Associa\u00e7\u00e3o Fundo de Incentivo \u00e0 Pesquisa","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006303","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:p>\n                    The present study aimed to investigate the effect of obstructive sleep apnea (OSA) and its treatment with continuous positive airway pressure (CPAP), the gold standard treatment for OSA on changes of telomere length and its associated mechanisms. In this mechanistic pilot study of a selective patient population (middle-aged men, BMI &lt; 35 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , moderate\u2013severe OSA), a 6-month randomized, double-blind, and sham-controlled clinical trial was conducted (Clinical Trials: NCT04872816, April 29, 2021 retrospectively registered). Participants were randomized to CPAP or sham-CPAP (randomization schema 2:1) and attended 7 visits, undergoing clinical assessments and blood collection to determine mean leukocyte telomere length (LTL) and assess metabolic and inflammatory markers. Among 127 individuals contacted, 46 met the inclusion criteria (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 30 in the CPAP group and\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 16 in the sham-CPAP group). At baseline, individuals in both groups were homogeneous with respect to LTL (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.106). Adherence during the intervention was measured in hours per night, recorded as 5.29 \u00b1 1.09 hours\/night for the sham-CPAP group and 5.71 \u00b1 0.19 hours\/night for the CPAP group, representing the last 30 days prior to the final visit. Three measurements of LTL were taken at baseline, 3 months, and 6 months. After 6 months of intervention, a statistically significant effect of treatment was observed (\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.001) on LTL, with the sham-CPAP group showing a greater reduction (1.0117 \u00b1 0.1552, 0.9457 \u00b1 0.0747, 0.8482 \u00b1 0.2163) compared with the CPAP group (1.0960 \u00b1 0.1122, 1.0521 \u00b1 0.1094, 1.0675 \u00b1 0.1225). Furthermore, a negative correlation between delta LTL and delta TNF-\u03b1 at Visit 7 and Visit 1 was found (\u03c1 = \u22120.216,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.003), primarily attributed to the sham-CPAP intervention (\u03c1 = \u22120.383,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.009) compared with CPAP use (\u03c1 = 0.021,\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.800). We conclude that CPAP, compared with sham-CPAP placebo, was associated with stabilization in LTL, potentially through modulation of TNF-\u03b1.\n                  <\/jats:p>","DOI":"10.1177\/15491684261428017","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T04:47:14Z","timestamp":1773722834000},"page":"211-218","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Obstructive Sleep Apnea and CPAP on Telomere Length and Its Associated Mechanisms: A Pilot Study"],"prefix":"10.1177","volume":"29","author":[{"given":"Priscila Farias","family":"Tempaku","sequence":"first","affiliation":[{"name":"Departamento de Psicobiologia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."},{"name":"Instituto do Sono, Associa\u00e7\u00e3o Fundo de Incentivo \u00e0 Pesquisa (AFIP), S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e2nia","family":"D\u2019Almeida","sequence":"additional","affiliation":[{"name":"Departamento de Psicobiologia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia Maria Affonso","family":"da Silva","sequence":"additional","affiliation":[{"name":"Departamento de Psicobiologia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia","family":"Bittencourt","sequence":"additional","affiliation":[{"name":"Departamento de Psicobiologia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Tufik","sequence":"additional","affiliation":[{"name":"Departamento de Psicobiologia, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo, Brazil."},{"name":"Instituto do Sono, Associa\u00e7\u00e3o Fundo de Incentivo \u00e0 Pesquisa (AFIP), S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,3,16]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2014.07.003"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00327.2006"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.32607\/20758251-2012-4-2-44-61"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aab3389"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06639.x"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.09.034"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg208"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2010.04.020"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132009000900009"},{"key":"e_1_3_2_11_1","first-page":"89","article-title":"A self-assessment questionnaire for the determination of morningness\u2013eveningness types in Brazil","volume":"341","author":"Benedito-Silva AA","year":"1990","unstructured":"10.Benedito-Silva AA, et al. 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