{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T08:35:47Z","timestamp":1792917347755,"version":"4.5.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2026,12,1]]},"abstract":"<jats:p>\n                    Huntington\u2019s disease (HD) is an inherited hyperkinetic movement disorder allied with chorea, cognitive impairment, and psychological disorders. Nerolidol (NRD) is a natural sesquiterpene alcohol obtained from many plants that has been shown to display neuroprotective properties. The current study focused on investigating the mechanism behind the neuroprotective role of NRD against 3-nitropropionic acid (3-NP)-induced neurotoxicity in experimental animals. Initial prediction was carried out through computational modeling (\n                    <jats:italic toggle=\"yes\">in silico<\/jats:italic>\n                    ), followed by a series of\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in\u00a0vivo<\/jats:italic>\n                    experiments utilizing batteries of behavioral and molecular tests. Molecular docking was performed using Schr\u00f6dinger (Maestro 2.0) to further explore NRD\u2019s neuroprotective capacity against 3-NP-induced neurotoxicity in SH-SY5Y cell lines and rats. For the\n                    <jats:italic toggle=\"yes\">in\u00a0vivo<\/jats:italic>\n                    study, 24 adult Wistar rats were randomly divided into four different groups, while NRD (50 and 100 mg\/kg) was chosen to study their neuroprotective impact against HD-like symptoms utilizing different behavioral, biochemical, and histopathological parameters.\n                    <jats:italic toggle=\"yes\">In silico<\/jats:italic>\n                    studies demonstrated that NRD has a high binding affinity for active sites of targeted enzymes, while\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    data showed that NRD can counteract the neurotoxic effects of 3-NP in SH-SY5Y cells. NRD therapy (50 and 100 mg\/kg) significantly improved motor activity, levels of malondialdehyde and glutathione, and histopathological changes. The findings revealed that NRD offers antioxidant and neuroprotective effects against 3-NP-induced neurotoxicity. The observed results indicated that NRD may exert its effects by activating the Nrf2 and heme oxygenase-1 pathways. Thus, it is suggested that it may be employed as an alternative treatment to fight against neurotoxicity.\n                  <\/jats:p>","DOI":"10.1177\/15491684261449703","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:24:41Z","timestamp":1780921481000},"page":"287-300","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Nerolidol Mitigates 3-Nitropropionic Acid-Induced Neurotoxicity:\n                    <i>In Silico<\/i>\n                    ,\n                    <i>In Vitro<\/i>\n                    , and\n                    <i>In Vivo<\/i>\n                    Approach"],"prefix":"10.1177","volume":"29","author":[{"given":"Ritika","family":"Devi","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Central University of Punjab, Bathinda, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhirendra","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Central University of Punjab, Bathinda, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Central University of Punjab, Bathinda, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubham","family":"Upadhayay","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Central University of Punjab, Bathinda, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash","family":"Jangid","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Laboratory of Organic and Medicinal Chemistry, Central University of Punjab, Bathinda, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Laboratory of Organic and Medicinal Chemistry, Central University of Punjab, Bathinda, India."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7978-1043","authenticated-orcid":false,"given":"Puneet","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Central University of Punjab, Bathinda, India."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13413"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04372-5"},{"key":"e_1_3_3_4_1","article-title":"Current and possible future therapeutic options for Huntington\u2019s disease","volume":"14","author":"Palpagama TH","year":"2022","unstructured":"3.Palpagama TH, , Kwakowsky A, , Faull R, et al. 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