{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T01:20:28Z","timestamp":1793841628102,"version":"4.6.1"},"reference-count":36,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Shenzhen Longgang District Science and Technology Innovation Special Fund Medical and Health Science and Technology Project in 2024","award":["LGWJ2024-7"],"award-info":[{"award-number":["LGWJ2024-7"]}]},{"name":"the Research Topics for Health Education and Promotion Work in Shenzhen in 2024","award":["SJC202426"],"award-info":[{"award-number":["SJC202426"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2026,12,1]]},"abstract":"<jats:p>\n                    Sarcopenia attenuates independence and mobility in older adults, and scalable nonpharmacological interventions are needed. This trial evaluated whether a 12-week exercise program improves activities of daily living, muscle mass and strength, physical performance, and systemic inflammation in older adults with sarcopenia. In this 12-week randomized controlled trial, adults aged 60\u201375 years with sarcopenia were randomized 1:1 to a control group or an exercise group. The exercise group performed postprandial multicomponent training (37 min\/session, 3 days\/week), combining resistance and aerobic exercise. Outcomes were measured at baseline and at week 12. The primary endpoint was the Modified Barthel Index (MBI). Secondary endpoints were Appendicular Skeletal Muscle Mass Index (ASMI), handgrip strength, the 6-minute walk test (6MWT), the Timed Up and Go Test (TUGT), and serum interleukin-6 (IL-6) and tumor necrosis factor-\u03b1 (TNF-\u03b1). Of 224 enrolled participants, 120 were randomized and 94 were analyzed (control,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 49; exercise,\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    = 45). At week 12, the exercise group showed higher MBI (68.89 \u00b1 9.60 vs. 62.02 \u00b1 10.35;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.001), ASMI (6.074 \u00b1 0.904 vs. 5.295 \u00b1 0.739 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.001), and handgrip strength (22.78 \u00b1 5.02 vs. 19.95 \u00b1 4.25 kg;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.009); better 6MWT (395.6 \u00b1 55.6 vs. 363.7 \u00b1 53.8 minutes;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.005), shorter TUGT (6.76 \u00b1 1.41 vs. 7.66 \u00b1 1.55 seconds;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    = 0.005), and lower IL-6 (45.21 \u00b1 10.66 vs. 53.73 \u00b1 10.99 pg\/mL;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.001) and TNF-\u03b1 (38.09 \u00b1 8.64 vs. 45.45 \u00b1 8.07 pg\/mL;\n                    <jats:italic toggle=\"yes\">p<\/jats:italic>\n                    &lt; 0.001) compared with the control group. These findings suggested that a 12-week regular exercise program improved functional independence, muscle health, mobility, and inflammatory status in older adults with sarcopenia.\n                  <\/jats:p>","DOI":"10.1177\/15491684261449707","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T04:11:26Z","timestamp":1778213486000},"page":"277-286","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Regular Daily Exercise Improves Sarcopenia in Elderly Patients"],"prefix":"10.1177","volume":"29","author":[{"given":"Jiachuang","family":"Zheng","sequence":"first","affiliation":[{"name":"Health Examination Center, Longgang Central Hospital of Shenzhen, Shenzhen, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Longgang Central Hospital of Shenzhen, Shenzhen, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixia","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Longgang Central Hospital of Shenzhen, Shenzhen, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Longgang Central Hospital of Shenzhen, Shenzhen, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Longgang Central Hospital of Shenzhen, Shenzhen, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7194-934X","authenticated-orcid":false,"given":"Yuxia","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Longgang Central Hospital of Shenzhen, Shenzhen, Guangdong, China."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1959486"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cph4.70030"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jot.2020.04.002"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-42667-5_12"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18063165"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-017-0266-9"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0251com"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118398"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1106458"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.13225"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19138212"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2019.1012"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-25-0275"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2018.02.003"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1072986"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-019-02200-7"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S455736"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11020598"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gerinurse.2025.04.019"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9051386"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12801"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-019-1196-8"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13216570"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/sports13120444"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2019.12.012"},{"issue":"2","key":"e_1_3_2_27_1","first-page":"6","article-title":"Chinese expert consensus on prevention and intervention for elderly with sarcopenia (2023)","volume":"42","author":"Hua C","year":"2023","unstructured":"26.Hua C, , Wang Z, , Wu J, et al.; Chinese Geriatrics Society. Chinese expert consensus on prevention and intervention for elderly with sarcopenia (2023). 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