{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T08:35:44Z","timestamp":1792917344943,"version":"4.5.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Korean Ministry of Science and ICT","award":["RS-2025-16066686"],"award-info":[{"award-number":["RS-2025-16066686"]}],"id":[{"id":"https:\/\/ror.org\/01wpjm123","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Soonchunhyang University Research Fund","award":["2026-0030"],"award-info":[{"award-number":["2026-0030"]}],"id":[{"id":"https:\/\/ror.org\/03qjsrb10","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Rejuvenation Research"],"published-print":{"date-parts":[[2026,12,1]]},"abstract":"<jats:p>\n                    Identification of natural compounds that delay aging and prevent age-related neurodegeneration is a key goal in gerontology. Fucoxanthin, a marine-derived xanthophyll, exhibits potent antioxidant properties, yet its effects on organismal aging and specific molecular mechanisms remain underexplored. Here, we investigated the pro-longevity and neuroprotective effects of fucoxanthin using\n                    <jats:italic toggle=\"yes\">Caenorhabditis elegans<\/jats:italic>\n                    . Fucoxanthin supplementation significantly extended the mean lifespan of wild-type nematodes by 12.1% and improved health span, as evidenced by delayed age-related motility decline and enhanced resistance to oxidative stress. Notably, this lifespan extension occurred without compromising reproductive fitness. Genetic analysis revealed that the beneficial effects of fucoxanthin require the FOXO transcription factor DAF-16 and the autophagy-essential gene\n                    <jats:italic toggle=\"yes\">bec-1<\/jats:italic>\n                    . Furthermore, fucoxanthin treatment increased autophagic flux and upregulated the expression of SKN-1\/Nrf2-dependent detoxification genes,\n                    <jats:italic toggle=\"yes\">hsp-16.2<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">gst-4<\/jats:italic>\n                    . In nematode models of Alzheimer\u2019s and Parkinson\u2019s disease, fucoxanthin significantly ameliorated A\u03b2-induced paralysis and protected against dopaminergic neurodegeneration and \u03b1-synuclein accumulation in a DAF-16-dependent manner. Collectively, our findings demonstrate that fucoxanthin acts as a multitarget geroprotector that promotes healthy aging through the coordinated activation of DAF-16 and autophagy, suggesting its potential as a therapeutic intervention for age-related decline.\n                  <\/jats:p>","DOI":"10.1177\/15491684261460844","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T07:11:08Z","timestamp":1781680268000},"page":"315-324","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Fucoxanthin Promotes Longevity and Neuroprotection in\n                    <i>Caenorhabditis elegans<\/i>\n                    via DAF-16 and Autophagy Pathways"],"prefix":"10.1177","volume":"29","author":[{"given":"Seona","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, General Graduate School, Soonchunhyang University, Asan, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7697-1434","authenticated-orcid":false,"given":"Sang-Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, General Graduate School, Soonchunhyang University, Asan, Republic of Korea."},{"name":"Department of Medical Biotechnology, Soonchunhyang University, Asan, Republic of Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronj\/11.3.298"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.11.004"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2009.06.003"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01960"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02789"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9932218"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2004.03.012"},{"key":"e_1_3_2_9_1","first-page":"4310","article-title":"Resveratrol-induced augmentation of telomerase activity delays senescence of endothelial progenitor cells","volume":"124","author":"Wang XB","year":"2011","unstructured":"8.Wang XB, , Zhu L, , Huang J, et al. Resveratrol-induced augmentation of telomerase activity delays senescence of endothelial progenitor cells. Chin Med J (Engl) 2011;124:4310\u20134315.","journal-title":"Chin Med J (Engl)"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.02.020"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-022-00322-9"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1975"},{"key":"e_1_3_2_13_1","article-title":"Butein increases resistance to oxidative stress and lifespan with positive effects on the risk of age-related diseases in caenorhabditis elegans","volume":"13","author":"Kim S","year":"2024","unstructured":"12.Kim S, , Yoon H, , Park SK. Butein increases resistance to oxidative stress and lifespan with positive effects on the risk of age-related diseases in caenorhabditis elegans. Antioxidants (Basel) 2024;13.","journal-title":"Antioxidants (Basel)"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15121528"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/19768354.2025.2549756"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.929442"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf2029785"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.7b00805"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/md14040067"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2019.108757"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf400015k"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2015.08.009"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-4471-x"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01278"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.2307\/2344317"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0030025"},{"key":"e_1_3_2_27_1","article-title":"The role of fucoxanthin as a potent nrf2 activator via akt\/gsk-3beta\/fyn axis against amyloid-beta peptide-induced oxidative damage","volume":"12","author":"Lee N","year":"2023","unstructured":"26.Lee N, , Youn K, , Yoon JH, , Lee B, , Kim DH, , Jun M. The role of fucoxanthin as a potent nrf2 activator via akt\/gsk-3beta\/fyn axis against amyloid-beta peptide-induced oxidative damage. Antioxidants (Basel) 2023;12.","journal-title":"Antioxidants (Basel)"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0098-2997(03)00030-X"},{"key":"e_1_3_2_29_1","article-title":"Anti-Oxidant and anti-aging effects of phlorizin are mediated by DAF-16-induced stress response and autophagy in caenorhabditis elegans","volume":"11","author":"Park S","year":"2022","unstructured":"28.Park S, , Park SK. Anti-Oxidant and anti-aging effects of phlorizin are mediated by DAF-16-induced stress response and autophagy in caenorhabditis elegans. Antioxidants (Basel) 2022;11.","journal-title":"Antioxidants (Basel)"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5618"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/md19030132"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05904"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0040024"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05837"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450116666150825113655"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1393721"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045256"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2474"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/npjparkd.2015.22"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.12.078"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2013.05.014"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq285"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.06.008"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3267"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3300"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.01.030"}],"container-title":["Rejuvenation Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15491684261460844","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/15491684261460844","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/15491684261460844","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T07:48:27Z","timestamp":1792914507000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/15491684261460844"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,17]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,12,1]]}},"alternative-id":["10.1177\/15491684261460844"],"URL":"https:\/\/doi.org\/10.1177\/15491684261460844","relation":{},"ISSN":["1549-1684","1557-8577"],"issn-type":[{"value":"1549-1684","type":"print"},{"value":"1557-8577","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,17]]}}}