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Drug-induced lung injuries, including interstitial pneumonitis, acute respiratory distress syndrome, and fibrosis, are commonly observed, with agents such as bleomycin, cyclophosphamide, and busulfan. Approximately 10% of patients undergoing chemotherapy experience pulmonary complications, necessitating effective management strategies. Emerging evidence suggests that natural products, particularly antioxidants and plant-derived compounds like ellagic acid, can mitigate chemotherapy-induced pulmonary toxicity by counteracting oxidative stress and inflammation. We aim to summarize the toxic implications of chemotherapeutic drugs on the respiratory system, elucidating the underlying pathophysiological mechanisms. It also explores potential therapeutic interventions, including natural products, to reduce pulmonary toxicity. A thorough understanding of overall mechanisms will aid in the advancement of targeted strategies to improve the efficacy of cancer treatment while minimizing adverse effects.<\/jats:p>","DOI":"10.1177\/15491684261462405","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:24:49Z","timestamp":1785212689000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary Toxicity of Chemotherapy: Mechanisms, Challenges, and the Promise of Natural Therapeutics and Antioxidants"],"prefix":"10.1177","author":[{"given":"Saba","family":"Beigh","sequence":"first","affiliation":[{"name":"Department of Public Health, Faculty of Applied Medical Sciences, Al-Baha University, Al-Baha, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haroon Habib","family":"Beigh","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Ala-Too International University, Bishkek, Kyrgyztan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fauzia","family":"Ashfaq","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Idreesh","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha Assad","family":"Assiri","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abrar","family":"Turki","sequence":"additional","affiliation":[{"name":"Clinical Nutrition Department, College of Applied Medical Sciences, University of Hafr Al Batin, Hafr Al Batin, Eastern Province, Saudi Arabia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4519-721X","authenticated-orcid":false,"given":"Mirza Masroor Ali","family":"Beg","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Ala-Too International University, Bishkek, Kyrgyztan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-23-0411"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10937404.2019.1643539"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/20503121211034366"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2022.02.007"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-09-0254"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma16145164"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14030627"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-680"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2024.100744"},{"issue":"4","key":"e_1_3_4_11_1","first-page":"211","article-title":"Infiltrative lung diseases: Complications of novel antineoplastic agents in patients with hematological malignancies","volume":"15","author":"Vahid B","year":"2008","unstructured":"10.Vahid B, , Marik PE. 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