{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:32:11Z","timestamp":1785817931340,"version":"3.56.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin EEG Neurosci"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:p>\n                    EEG and cerebral blood flow abnormalities have been documented in chronic cocaine abusers. To identify possible relationships between EEG and blood flow changes and their relationship to the intensity of cocaine use, we recorded the resting eyes-closed EEG and anterior (ACA) and middle (MCA) cerebral artery blood flow velocity during systole (V\n                    <jats:sub>S<\/jats:sub>\n                    ) and diastole (V\n                    <jats:sub>D<\/jats:sub>\n                    ) by transcranial Doppler (TCD) sonography of 99 (76 male, 23 female; mean [SD] age 34.3 [5.2] years, 8.6 [5.5] years of cocaine use, 17.8 [7.7] days of cocaine use in month prior to screening) cocaine users within 5 days of admission to a closed research unit. Forty-two non-drug-using, age-matched control subjects (22 male, 20 female) were tested as outpatients. A 3-minute period of resting EEG was recorded from 16 standard scalp electrodes. Artifact-free EEG was converted to six frequency bands (delta, theta, alpha1, alpha2, beta1 and beta2) using a Fast Fourier Transform. Pulsatility index (PI) was calculated as a measure of small vessel resistance.\n                  <\/jats:p>\n                  <jats:p>\n                    Cocaine users had decreased V\n                    <jats:sub>D<\/jats:sub>\n                    and increased PI in the MCA, with no difference in V\n                    <jats:sub>S<\/jats:sub>\n                    , and reduced EEG theta, beta1 and beta2 absolute power in posterior brain regions. Recent cocaine use was positively associated with MCA PI (r = 0.27, p &lt; 0.001) and negatively associated with low frequency EEG power (delta power: r = \u22120.25, p &lt; 0.002; theta power: r = \u22120.29, p&lt; 0.001). EEG beta1 (r = \u22120.211, p &lt; 0.05) and beta2 (r = \u22120.176, p &lt; 0.05) power measures were correlated with PI. These observations suggest that EEG and TCD changes reflect related physiological processes during early cocaine abstinence.\n                  <\/jats:p>","DOI":"10.1177\/155005940904000111","type":"journal-article","created":{"date-parts":[[2012,2,22]],"date-time":"2012-02-22T16:03:18Z","timestamp":1329926598000},"page":"39-42","source":"Crossref","is-referenced-by-count":7,"title":["EEG and Cerebral Blood Flow Velocity Abnormalities in Chronic Cocaine Users"],"prefix":"10.1177","volume":"40","author":[{"given":"Marc L.","family":"Copersino","sequence":"first","affiliation":[{"name":"Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institues of Health, Department of Health and Human Services, Biomedical Research Center, Baltimore, Maryland"},{"name":"Alcohol and Drug Abuse Treatment Program at McLean Hospital"},{"name":"Department of Psychiatry at Harvard Medical School. Belmont, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald I.","family":"Herning","sequence":"additional","affiliation":[{"name":"Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institues of Health, Department of Health and Human Services, Biomedical Research Center, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren","family":"Better","sequence":"additional","affiliation":[{"name":"Molecular Neuropsychiatry Branch, Intramural Research Program, National Institute on Drug Abuse, National Institues of Health, Department of Health and Human Services, Biomedical Research Center, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Lud","family":"Cadet","sequence":"additional","affiliation":[{"name":"Department of Psychiatry at Harvard Medical School. Belmont, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Gorelick","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology and Therapeutics Branch, Intramural Research Program, National Institute on Drug Abuse, National Institues of Health, Department of Health and Human Services, Biomedical Research Center, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2009,1,1]]},"reference":[{"key":"bibr1-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.2.341"},{"key":"bibr2-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1161\/hs1001.097041"},{"key":"bibr3-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000074572.91827.F4"},{"key":"bibr4-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2006.055970"},{"key":"bibr5-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.4.495"},{"key":"bibr6-155005940904000111","doi-asserted-by":"publisher","DOI":"10.3109\/00952999009001592"},{"key":"bibr7-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1996.tb00041.x"},{"key":"bibr8-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.043s2028.x"},{"key":"bibr9-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.1991.hed3101017.x"},{"key":"bibr10-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.54.9.803"},{"key":"bibr11-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2002.10399983"},{"key":"bibr12-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.176.3.2389042"},{"key":"bibr13-155005940904000111","first-page":"1206","volume":"32","author":"Holman BL","year":"1991","journal-title":"J Nucl Med"},{"key":"bibr14-155005940904000111","first-page":"876","volume":"31","author":"Weber DA","year":"1990","journal-title":"J Nucl Med"},{"key":"bibr15-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.5.4.419"},{"key":"bibr16-155005940904000111","first-page":"1902","volume":"35","author":"Levin JM","year":"1994","journal-title":"J Nucl Med"},{"key":"bibr17-155005940904000111","first-page":"1902","volume":"35","author":"Levin JM","year":"1995","journal-title":"J Nucl Med"},{"key":"bibr18-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00228-5"},{"key":"bibr19-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(98)00141-9"},{"key":"bibr20-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4927(90)90013-V"},{"key":"bibr21-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4603(94)90015-9"},{"key":"bibr22-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(01)00236-6"},{"key":"bibr23-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1159\/000119160"},{"key":"bibr24-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(95)02474-B"},{"key":"bibr25-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(95)00575-7"},{"key":"bibr26-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(97)00058-6"},{"key":"bibr27-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(97)00211-X"},{"key":"bibr28-155005940904000111","first-page":"1087","volume":"41","author":"Herning RI","year":"1997","journal-title":"Psychiatry"},{"key":"bibr29-155005940904000111","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1176\/jnp.11.2.209","volume":"11","author":"Alper KR","year":"1999","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"bibr30-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1159\/000026678"},{"key":"bibr31-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1097\/ADM.0b013e3180f493ee"},{"key":"bibr32-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(00)00454-5"},{"key":"bibr33-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(99)00309-0"},{"key":"bibr34-155005940904000111","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(02)01362-8"},{"key":"bibr35-155005940904000111","volume-title":"National Institute of Mental Health Diagnostic Interview Schedule Version III-R","author":"Robins S","year":"1988"},{"key":"bibr36-155005940904000111","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association.","year":"1987","edition":"3"},{"key":"bibr37-155005940904000111","volume-title":"Administration, Scoring, and Procedures for SCL-90R: Manual II","author":"Derogatis LR","year":"1983"},{"key":"bibr38-155005940904000111","unstructured":"Chamberlin H. 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