{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:09:39Z","timestamp":1791216579093,"version":"4.1.0"},"reference-count":12,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2014,10,17]],"date-time":"2014-10-17T00:00:00Z","timestamp":1413504000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin EEG Neurosci"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Periodic lateralized epileptiform discharges (PLEDs) are an electroencephalographic pattern recorded in the setting of a variety of brain abnormalities. It is best recognized for its association with acute viral encephalitis, stroke, tumor, or latestatus epilepticus. However, there are other conditions that have been recognized as the underlying pathology for PLEDs such as alcohol withdrawal, Creutzfeldt\u2013Jacob disease, anoxic brain injury, and hemiplegic migraine. However, there are only rare case reports of PLEDs in patients with neurosyphilis. Here, we report 2 patients presenting with encephalopathy and seizures with PLEDs, ipsilateral or contralateral to their main brain magnetic resonance imaging abnormalities. Further workup revealed neurosyphilis in both patients, one in association with human immunodeficiency virus (HIV) infection. Given the increasing incidence of neurosyphilis with or without HIV infection, these cases suggest neurosyphilis as a consideration in the differential for patients presenting with PLEDs.<\/jats:p>","DOI":"10.1177\/1550059414552704","type":"journal-article","created":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T01:28:45Z","timestamp":1413595725000},"page":"247-250","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Periodic Lateralized Epileptiform Discharges (PLEDs) in Patients With Neurosyphilis and HIV Infection"],"prefix":"10.1177","volume":"47","author":[{"given":"Kentaroh","family":"Takagaki","sequence":"first","affiliation":[{"name":"Department of Neurology, Georgetown University Hospital, Washington, DC, USA"},{"name":"Department of Systems Physiology of Learning, Leibniz Institute for Neurobiology, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan K.","family":"Morales","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Disease and Travel Medicine, Georgetown University Hospital, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Vitantonio","sequence":"additional","affiliation":[{"name":"Department of Neurology, Georgetown University Hospital, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Berkowitz","sequence":"additional","affiliation":[{"name":"Department of Radiology, Georgetown University Hospital, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L.","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Neurology, Georgetown University Hospital, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Princy N.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Disease and Travel Medicine, Georgetown University Hospital, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholam K.","family":"Motamedi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Georgetown University Hospital, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,10,17]]},"reference":[{"key":"bibr1-1550059414552704","doi-asserted-by":"publisher","DOI":"10.1017\/S0317167100007332"},{"key":"bibr2-1550059414552704","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.00921.x"},{"key":"bibr3-1550059414552704","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1684\/epd.2007.0058","volume":"9","author":"G\u00fcrses C","year":"2007","journal-title":"Epileptic Disord"},{"key":"bibr4-1550059414552704","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2008.05.003"},{"key":"bibr5-1550059414552704","doi-asserted-by":"publisher","DOI":"10.1177\/1550059413500652"},{"key":"bibr6-1550059414552704","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1998.tb01339.x"},{"key":"bibr7-1550059414552704","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1980.tb04318.x"},{"key":"bibr8-1550059414552704","doi-asserted-by":"publisher","DOI":"10.1097\/00004691-199611000-00007"},{"key":"bibr9-1550059414552704","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e32830184df"},{"key":"bibr10-1550059414552704","unstructured":"Centers for Disease Control and Prevention. Diseases characterized by genital, anal, or perianal ulcers: syphilis. http:\/\/www.cdc.gov\/std\/treatment\/2010\/genital-ulcers.htm. Updated 2011. Accessed July 7, 2014."},{"key":"bibr11-1550059414552704","first-page":"703","volume":"16","author":"Brightbill TC","year":"1995","journal-title":"AJNR Am J Neuroradiol"},{"key":"bibr12-1550059414552704","first-page":"314","volume":"22","author":"Bash S","year":"2001","journal-title":"AJNR Am J Neuroradiol"}],"container-title":["Clinical EEG and Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1550059414552704","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1550059414552704","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1550059414552704","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:13:07Z","timestamp":1777403587000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1550059414552704"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,17]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1177\/1550059414552704"],"URL":"https:\/\/doi.org\/10.1177\/1550059414552704","relation":{},"ISSN":["1550-0594","2169-5202"],"issn-type":[{"value":"1550-0594","type":"print"},{"value":"2169-5202","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,17]]}}}