{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T17:52:18Z","timestamp":1777571538390,"version":"3.51.4"},"reference-count":93,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2018,3,4]],"date-time":"2018-03-04T00:00:00Z","timestamp":1520121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","award":["Young Investigator Grant"],"award-info":[{"award-number":["Young Investigator Grant"]}],"id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Clin EEG Neurosci"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:p>Substance use disorders (SUDs) have a devastating impact on society and place a heavy burden on health care systems. Given that alcohol, tobacco, and cannabis use have the highest prevalence, further understanding of the underlying pathophysiology of these SUDs is crucial. Electroencephalography is an inexpensive, temporally superior, and translatable technique which enables investigation of the pathobiology of SUDs through the evaluation of various event-related potential components, including mismatch negativity (MMN). The goals of this review were to investigate the effects of acute and chronic alcohol, tobacco, and cannabis use on MMN among nonpsychiatric populations and patients with comorbid psychosis. A literature search was performed using the database PubMed, and 36 articles met our inclusion and exclusion criteria. We found a pattern of attenuation of MMN amplitude among patients with alcoholism across acute and chronic alcohol use, and this dysregulation was not heritable. Reports were limited, and results were mixed on the effects of acute and chronic tobacco and cannabis use on MMN. Reports on comorbid SUDs and psychosis were even fewer, and also presented mixed findings. These preliminary results suggest that MMN deficits may be associated with SUDs, specifically alcohol use disorder, and serve as a possible biomarker for treating these common disorders.<\/jats:p>","DOI":"10.1177\/1550059418760077","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T00:27:59Z","timestamp":1520209679000},"page":"226-237","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Using Mismatch Negativity to Investigate the Pathophysiology of Substance Use Disorders and Comorbid Psychosis"],"prefix":"10.1177","volume":"49","author":[{"given":"Jessica U.","family":"Ramlakhan","sequence":"first","affiliation":[{"name":"Temerty Centre for Therapeutic Brain Intervention, Division of Mood and Anxiety, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"},{"name":"Biobehavioural Addictions and Concurrent Disorders Research Laboratory (BACDRL), Additions Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Zomorrodi","sequence":"additional","affiliation":[{"name":"Temerty Centre for Therapeutic Brain Intervention, Division of Mood and Anxiety, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Downar","sequence":"additional","affiliation":[{"name":"Krembil Research Institute, University Health Network, Toronto, Ontario, Canada"},{"name":"Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"},{"name":"Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel M.","family":"Blumberger","sequence":"additional","affiliation":[{"name":"Temerty Centre for Therapeutic Brain Intervention, Division of Mood and Anxiety, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"},{"name":"Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"},{"name":"Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zafiris J.","family":"Daskalakis","sequence":"additional","affiliation":[{"name":"Temerty Centre for Therapeutic Brain Intervention, Division of Mood and Anxiety, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"},{"name":"Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"},{"name":"Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tony P.","family":"George","sequence":"additional","affiliation":[{"name":"Biobehavioural Addictions and Concurrent Disorders Research Laboratory (BACDRL), Additions Division, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"},{"name":"Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"},{"name":"Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kiang","sequence":"additional","affiliation":[{"name":"Temerty Centre for Therapeutic Brain Intervention, Division of Mood and Anxiety, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"},{"name":"Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"},{"name":"Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mera S.","family":"Barr","sequence":"additional","affiliation":[{"name":"Temerty Centre for Therapeutic Brain Intervention, Division of Mood and Anxiety, Centre for Addiction and Mental Health, Toronto, Ontario, Canada"},{"name":"Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada"},{"name":"Division of Brain and Therapeutics, Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,3,4]]},"reference":[{"key":"bibr1-1550059418760077","volume-title":"Neuroscience of Psychoactive Substance Use and Dependence","author":"World Health Organization","year":"2004"},{"key":"bibr2-1550059418760077","unstructured":"United Nations Office on Drugs and Crime. World drug report 2012. https:\/\/www.unodc.org\/documents\/data-and-analysis\/WDR2012\/WDR_2012_web_small.pdf.Published June 2012. Accessed February 3, 2018."},{"key":"bibr3-1550059418760077","unstructured":"United Nations Office on Drugs and Crime. World drug report 2016. https:\/\/www.unodc.org\/doc\/wdr2016\/WORLD_DRUG_REPORT_2016_web.pdf. Published May 2016. Accessed February 3, 2018."},{"key":"bibr4-1550059418760077","unstructured":"World Health Organization. Tobacco fact sheet. http:\/\/www.wpro.who.int\/mediacentre\/factsheets\/fs_201203_tobacco\/en\/. Accessed February 3, 2018."},{"key":"bibr5-1550059418760077","unstructured":"Substance Abuse And Mental Health Services Administration. Results from the 2015 National Survey on drug use and health: detailed tables. https:\/\/www.samhsa.gov\/data\/sites\/default\/files\/NSDUH-DetTabs-2015\/NSDUH-DetTabs-2015\/NSDUH-DetTabs-2015.pdf. Accessed February 3, 2018."},{"key":"bibr6-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(16)00104-8"},{"key":"bibr7-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(01)01134-9"},{"key":"bibr8-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.2009.01385.x"},{"key":"bibr9-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03450190043026"},{"key":"bibr10-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2005.04.016"},{"key":"bibr11-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1136\/tobaccocontrol-2013-051466"},{"key":"bibr12-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbp031"},{"key":"bibr13-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291714000191"},{"key":"bibr14-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24383"},{"key":"bibr15-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.12.006"},{"key":"bibr16-1550059418760077","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.0507e12"},{"key":"bibr17-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1980.tb08050.x"},{"key":"bibr18-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2000.tb04584.x"},{"key":"bibr19-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-008-0835-6"},{"key":"bibr20-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbt176"},{"key":"bibr21-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1093\/alcalc\/36.5.357"},{"key":"bibr22-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(89)90513-2"},{"key":"bibr23-1550059418760077","doi-asserted-by":"publisher","DOI":"10.2478\/s13380-012-0022-0"},{"key":"bibr24-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2013.09.007"},{"key":"bibr25-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1313287110"},{"key":"bibr26-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2012.09.029"},{"key":"bibr27-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.501"},{"key":"bibr28-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e32834cdc3f"},{"key":"bibr29-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.09.030"},{"key":"bibr30-1550059418760077","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S53687"},{"key":"bibr31-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2001.113989"},{"key":"bibr32-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12730"},{"key":"bibr33-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245862"},{"key":"bibr34-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(95)00009-7"},{"key":"bibr35-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1999.tb04674.x"},{"key":"bibr36-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.005"},{"key":"bibr37-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1995.tb01555.x"},{"key":"bibr38-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0511(95)05174-0"},{"key":"bibr39-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-012-2816-8"},{"key":"bibr40-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(93)90097-W"},{"key":"bibr41-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1999.tb04069.x"},{"key":"bibr42-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2000.tb01989.x"},{"key":"bibr43-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-2457(01)00490-4"},{"key":"bibr44-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1997.tb03804.x"},{"key":"bibr45-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1998.tb03920.x"},{"key":"bibr46-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02218.x"},{"key":"bibr47-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000148109.79230.28"},{"key":"bibr48-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000107199.26934.46"},{"key":"bibr49-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)00309-Q"},{"key":"bibr50-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntp044"},{"key":"bibr51-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1177\/0269881109348158"},{"key":"bibr52-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2418"},{"key":"bibr53-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1159\/000092541"},{"key":"bibr54-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1080\/14622200600576669"},{"key":"bibr55-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2005.01.001"},{"key":"bibr56-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpsycho.2005.07.014"},{"key":"bibr57-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2004.11.009"},{"key":"bibr58-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1093\/ntr\/ntp052"},{"key":"bibr59-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1159\/000111536"},{"key":"bibr60-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e3181f0c9c6"},{"key":"bibr61-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2012.01.026"},{"key":"bibr62-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.08.015"},{"key":"bibr63-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-010-0097-y"},{"key":"bibr64-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.05.035"},{"key":"bibr65-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6526437"},{"key":"bibr66-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.05.011"},{"key":"bibr67-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-012-2676-2"},{"key":"bibr68-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2015.07.002"},{"key":"bibr69-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1177\/1550059413495533"},{"key":"bibr70-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1159\/000013896"},{"key":"bibr71-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.186.1.8416587"},{"key":"bibr72-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2008.11.029"},{"key":"bibr73-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbq079"},{"key":"bibr74-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2011.02.017"},{"key":"bibr75-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-010-0146-6"},{"key":"bibr76-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1111\/add.13646"},{"key":"bibr77-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1997.tb09925.x"},{"key":"bibr78-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200003200-00032"},{"key":"bibr79-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.01.071"},{"key":"bibr80-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2006.02.010"},{"key":"bibr81-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1186\/s40810-014-0002-4"},{"key":"bibr82-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0675-x"},{"key":"bibr83-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300477"},{"key":"bibr84-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145707008176"},{"key":"bibr85-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1177\/0269881109102606"},{"key":"bibr86-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2017.81"},{"key":"bibr87-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.162"},{"key":"bibr88-1550059418760077","doi-asserted-by":"publisher","DOI":"10.3109\/09540261.2011.618827"},{"key":"bibr89-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1177\/0269881115587929"},{"key":"bibr90-1550059418760077","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2014.00003"},{"key":"bibr91-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1177\/1550059416630483"},{"key":"bibr92-1550059418760077","first-page":"1359","volume":"2009","author":"Iwahashi M","year":"2009","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"key":"bibr93-1550059418760077","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.12758"}],"container-title":["Clinical EEG and Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1550059418760077","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1550059418760077","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1550059418760077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T19:13:29Z","timestamp":1777403609000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1550059418760077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,4]]},"references-count":93,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1177\/1550059418760077"],"URL":"https:\/\/doi.org\/10.1177\/1550059418760077","relation":{},"ISSN":["1550-0594","2169-5202"],"issn-type":[{"value":"1550-0594","type":"print"},{"value":"2169-5202","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,4]]}}}