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Converging evidence has suggested that both the descending corticospinal pathway and ascending sensory feedback pathway are involved in the generation of corticomuscular coupling. The present study aimed to explore the corticomuscular coupling during hand motor task with enhancing force and steady-state force. Twenty healthy subjects performed precision grip with enhancing and static force using the right hand with visual feedback of exerted force. Mutual information and Granger causal connectivity were assessed between electroencephalography (EEG) over primary motor cortex and electromyography (EMG) recordings, and statistically analyzed. The results showed that the mutual information value was significantly larger for static force in the beta and alpha frequency band than enhancing force state. Furthermore, compared with enhancing force, the Granger causal connectivity of descending pathways from cortex to muscle was significantly larger for static force in the beta and high alpha frequency band (10-20 Hz), indicating the connection between the primary motor cortex and muscle was strengthened for static force. In summary, the hand grip with static force resulted in an increasing corticomuscular coupling from EEG over the primary motor cortex to EMG compared with enhancing force, implying more attention was required in the static force state. These results have important implications toward motor rehabilitation therapy design for the recovery of impaired hand motor functions.<\/jats:p>","DOI":"10.1177\/1550059420933149","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T22:27:32Z","timestamp":1593642452000},"page":"436-443","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Enhanced Descending Corticomuscular Coupling During Hand Grip With Static Force Compared With Enhancing Force"],"prefix":"10.1177","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5971-8012","authenticated-orcid":false,"given":"Lin","family":"Gao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Manufacturing Systems Engineering, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, People\u2019s Republic of China"},{"name":"School of Mechanical Engineering, Xi\u2019an Jiaotong University, Xi\u2019an, 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