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The current study focused on its electrophysiological characteristics, especially power spectral density (PSD). Resting state with eyes opened magnetoencephalography data were collected from 21 patients with BD and 22 healthy controls. The whole brain's PSD was calculated from source reconstructed waveforms at each frequency band (delta: 1-3\u2005Hz, theta: 4-7\u2005Hz, alpha: 8-12\u2005Hz, low beta: 13-19\u2005Hz, high beta: 20-29\u2005Hz, and gamma: 30-80\u2005Hz). We compared PSD values on the marked vertices at each frequency band between healthy and patient groups using a Mann-Whitney rank test to examine the relationship between significantly different PSD and clinical measures. The PSD in patients with BD was significantly decreased in lower frequency bands, mainly in the default mode network (DMN) areas (bilateral medial prefrontal cortex, bilateral precuneus, left inferior parietal lobe, and right temporal cortex in the alpha band) and salience network areas (SAL; left anterior insula [AI] at the delta band, anterior cingulate cortex at the theta band, and right AI at the alpha band). No significant differences in PSD were observed at low beta and high beta. PSD was not correlated with age or other clinical scales. Altered PSDs of the DMN and SAL were observed in the delta, theta, and alpha bands. These alterations contribute to the vulnerability of BD through the disturbance of self-referential mental activity and switching between the default mode and frontoparietal networks.<\/jats:p>","DOI":"10.1177\/15500594211050487","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T08:47:18Z","timestamp":1634892438000},"page":"574-583","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["The Characteristics of Power Spectral Density in Bipolar Disorder at the Resting State"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2823-1324","authenticated-orcid":false,"given":"Masakazu","family":"Sunaga","sequence":"first","affiliation":[{"name":"Gunma Prefectural Psychiatric Medical Center, Isesaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichi","family":"Takei","sequence":"additional","affiliation":[{"name":"Gunma 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